Host resistance influences patterns of experimental viral adaptation and virulence evolution

Virulence
J L Kubinak, W K Potts

Abstract

Infectious diseases are major threats to all living systems, so understanding the forces of selection that limit the evolution of more virulent pathogens is of fundamental importance; this includes the practical application of identifying possible mitigation strategies for at-risk host populations. The evolution of more virulent pathogens has been classically understood to be limited by the tradeoff between within-host growth rate and transmissibility. Importantly, heterogeneity among hosts can influence both of these factors. However, despite our substantial understanding of how the immune system operates to control pathogen replication during infection, we have only a limited appreciation of how variability in intrinsic (i.e., genetically determined) levels of host resistance influences patterns of pathogen adaptation and virulence evolution. Here, we describe results from experimental evolution studies using a model host-pathogen (virus-mammal) system; we demonstrate that variability in intrinsic levels of resistance among host genotypes can have significant effects on patterns of pathogen adaptation and virulence evolution during serial passage. Both the magnitude of adaptive response as well as the degree of pathogen speci...Continue Reading

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Related Concepts

Immune System
Pathogenicity
Mice, Inbred BALB C
Pathogenic Organism
Biological Adaptation
Mice, Inbred DBA
Leukemia, Experimental
Host-Pathogen Interactions
Papilloma, Shope
Virulence

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