Host response to Candida albicans bloodstream infection and sepsis

Virulence
Seána DugganOliver Kurzai

Abstract

Candida albicans is a major cause of bloodstream infection which may present as sepsis and septic shock - major causes of morbidity and mortality world-wide. After invasion of the pathogen, innate mechanisms govern the early response. Here, we outline the models used to study these mechanisms and summarize our current understanding of innate immune responses during Candida bloodstream infection. This includes protective immunity as well as harmful responses resulting in Candida induced sepsis. Neutrophilic granulocytes are considered principal effector cells conferring protection and recognize C. albicans mainly via complement receptor 3. They possess a range of effector mechanisms, contributing to elimination of the pathogen. Neutrophil activation is closely linked to complement and modulated by activated mononuclear cells. A thorough understanding of these mechanisms will help in creating an individualized approach to patients suffering from systemic candidiasis and aid in optimizing clinical management.

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Citations

Sep 20, 2015·Fungal Genetics and Biology : FG & B·Fabian EssigOliver Kurzai
Nov 9, 2016·Microbiological Research·Aneta Sowa-JasiłekMałgorzata Cytryńska
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Oct 7, 2017·Frontiers in Cellular and Infection Microbiology·Marcin ZawrotniakMaria Rapala-Kozik
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Apr 17, 2020·Frontiers in Immunology·Sravya SreekantapuramIlse D Jacobsen
Apr 6, 2018·Frontiers in Immunology·Maria T E PraußeMarc Thilo Figge
May 12, 2017·Current Genetics·Ronny MartinOliver Kurzai
Jan 29, 2019·Frontiers in Immunology·Marcin Okrój, Jan Potempa
Jun 5, 2019·Deutsches Ärzteblatt International·Marie von Lilienfeld-ToalOliver Kurzai
Dec 3, 2020·Frontiers in Microbiology·Carmen Rodríguez-CerdeiraJosé Luís González-Cespón
Dec 24, 2018·The Journal of Critical Care Medicine·Mircea Gabriel MureșanArio Santini
Jul 15, 2021·ACS Infectious Diseases·David J LowesBrian M Peters

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Methods Mentioned

BETA
PCR

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