Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice.

Journal of Pediatric Gastroenterology and Nutrition
Geoffrey A PreidisJames Versalovic

Abstract

Beneficial microbes and probiotics are promising agents for the prevention and treatment of enteric and diarrheal diseases in children; however, little is known about their in vivo mechanisms of action. We used a neonatal mouse model of rotavirus diarrhea to gain insight into how probiotics ameliorate acute gastroenteritis. Rotavirus-infected mice were treated with 1 of 2 strains of human-derived Lactobacillus reuteri. We assessed intestinal microbiome composition with 16S metagenomic sequencing, enterocyte migration and proliferation with 5-bromo-2'-deoxyuridine, and antibody and cytokine concentrations with multiplex analyses of intestinal explant cultures. Probiotics reduced diarrhea duration, improved intestinal histopathology, and enhanced intestinal microbiome richness and phylogenetic diversity. The magnitude of reduction of diarrhea by probiotics was strain specific and influenced by nutritional status. L reuteri DSM 17938 reduced diarrhea duration by 0, 1, and 2 days in underweight, normal weight, and overweight pups, respectively. The magnitude of reduction of diarrhea duration correlated with increased enterocyte proliferation and migration. Strain ATCC PTA 6475 reduced diarrhea duration by 1 day in all of the mice w...Continue Reading

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Citations

Mar 15, 2014·The Journal of Infectious Diseases·Luther A Bartelt, Richard L Guerrant
Dec 15, 2015·Revista Argentina de microbiología·Lucia MaffeyLorena Garaicoechea
Jun 14, 2015·The Journal of Nutritional Biochemistry·Geoffrey A PreidisJoseph F Petrosino
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Sep 8, 2016·PloS One·Lucía MaffeyViviana Parreño
Aug 5, 2017·Clinical Microbiology Reviews·Marwa K IbrahimPeter C Melby
May 5, 2018·Frontiers in Microbiology·Qinghui MuXin M Luo
Jan 14, 2021·Foods·Aroa Lopez-SantamarinaAlberto Cepeda
Jan 26, 2021·Frontiers in Cellular and Infection Microbiology·Andrew HyoungJin KimMegan T Baldridge

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