Abstract
Non-melanoma skin cancer (NMSC) is the most common cancer in the US, and having multiple lesions conveys substantial cost and morbidity for the individual involved. Although there are data available on risk factors for NMSC, there are currently few studies that identify specific risk factors for development of multiple NMSCs. We evaluated host risk factors for multiple NMSCs among men (Health Professionals Follow-up Study) and women (Nurses' Health Study). Compared with individuals with a single NMSC, having greater number of sunburns was a risk factor for developing ≥ 2 NMSCs [≥ 10 sunburns, cumulative relative risk (RR) = 1.21, 95% confidence interval (CI): 1.07-1.36] and a higher risk of developing ≥ 11 NMSCs (≥10 sunburns, RR = 2.33, 95% CI: 1.57-3.46). Inability-to-tan was associated with risk of developing ≥ 2 NMSCs (cumulative RR = 1.29, 95% CI: 1.18-1.40) and a higher risk of developing ≥ 11 NMSCs (RR = 1.91, 95% CI: 1.50-2.43). Men had an increased risk of developing ≥ 2 NMSCs (cumulative RR = 1.53, 95% CI: 1.40-1.66). Risk of developing 2-4, 5-10 and ≥11 NMSCs increased with age. Other risk factors for developing ≥ 2 NMSCs included red natural hair colour (cumulative RR = 1.23, 95% CI: 1.07-1.42), family history of me...Continue Reading
References
Sep 1, 1979·Journal of the American Academy of Dermatology·K H KaidbeyA M Kligman
May 1, 1992·Annals of Epidemiology·D J HunterF E Speizer
Jun 24, 1992·JAMA : the Journal of the American Medical Association·M R KaragasR S Stern
May 1, 1986·American Journal of Epidemiology·G A ColditzF E Speizer
Nov 1, 1993·The Journal of Investigative Dermatology·B A GilchrestM Yaar
Oct 1, 1996·Photodermatology, Photoimmunology & Photomedicine·N Bech-Thomsen, H C Wulf
Oct 31, 1998·Photochemistry and Photobiology·J M MenterI Willis
Oct 28, 1999·The Journal of Investigative Dermatology. Symposium Proceedings·B A Gilchrest, M S Eller
Dec 15, 2000·Archives of Dermatology·I Marcil, R S Stern
Mar 21, 2002·Journal of the National Cancer Institute·Kana WuEdward L Giovannucci
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Esther K WeiGraham A Colditz
Mar 8, 2005·Mutation Research·Nita Agar, Antony R Young
Feb 24, 2006·British Journal of Cancer·E S SchernhammerC S Fuchs
Mar 12, 2008·Archives of Internal Medicine·Abrar A QureshiDavid J Hunter
Mar 17, 2010·Archives of Dermatology·Howard W RogersBrett M Coldiron
Aug 10, 2010·PloS One·Jing XieJiali Han
Aug 18, 2010·Archives of Dermatology·Ville KiiskiTamar Nijsten
Oct 27, 2011·Cancer Research·Hongmei NanJiali Han
Citations
Sep 20, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kachiu C LeeRaymond G Dufresne
May 28, 2014·The British Journal of Dermatology·J EderF Trautinger
Jan 13, 2017·PloS One·Luba M PardoTamar Nijsten
Oct 16, 2015·Revista de saúde pública·Samir PereiraAna Maria Quinteiro Ribeiro
May 20, 2017·American Journal of Epidemiology·Brian M LinGary C Curhan
May 29, 2015·Journal of Cutaneous Medicine and Surgery·Lyn C GuentherUNKNOWN Canadian Non-melanoma Skin Cancer Guidelines Committee
Jul 31, 2020·Pharmaceutical Development and Technology·Ümran Yamanİpek Eroğlu
Feb 6, 2017·Dermatology and Therapy·Zoe ApallaXavier Castellsagué
Feb 28, 2019·Health Science Reports·Eden Rebecca PadayacheeStefan Barth