Host-specific effect of P1 exchange between two potyviruses.

Molecular Plant Pathology
B SalvadorC Simón-Mateo

Abstract

The potyviruses Plum pox virus (PPV) and Tobacco vein mottling virus (TVMV) have distinct host ranges and induce different symptoms in their common herbaceous hosts. To test the relevance of the P1 protein in host compatibility and pathogenicity, hybrid viruses were constructed in which the P1 coding sequence of PPV was completely or partially replaced by the corresponding sequences from TVMV. Infections induced by these chimeric viruses revealed that the TVMV P1 and a PPV/TVMV hybrid P1 proteins are functionally equivalent in herbaceous plants to the P1 protein of a PPV isolate adapted to these hosts, in spite of having high sequence divergence. Moreover, the presence of TVMV P1 sequences enhanced the competence of a low-infectivity PPV-D-derived chimera in Nicotiana clevelandii. Conversely, all PPV/TVMV hybrids were unable to infect Prunus persicae, a specific host for PPV, suggesting that TVMV P1 is not functionally competent in this plant. Together, these data highlight the importance of the P1 protein in defining the virus host range.

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Citations

Sep 23, 2008·Biochemical Genetics·Satendra K MangrauthiaShelly Praveen
Sep 27, 2012·Virus Genes·B ParameswariC Chinnaraja
Apr 1, 2011·Journal of Biosciences·Jana Rohozková, Milan Navrátil
Dec 4, 2012·Viruses·Jiri SochorRene Kizek
Jan 10, 2014·Molecular Plant-microbe Interactions : MPMI·Laurence Svanella-DumasThierry Candresse
Feb 6, 2016·BMC Evolutionary Biology·Beatriz Mengual-ChuliáIgnacio G Bravo
Jan 7, 2015·Virology·Hongying ShanBernardo Rodamilans
Feb 8, 2013·The Journal of General Virology·Bernardo RodamilansJuan Antonio García
Sep 9, 2011·The Journal of General Virology·Vicente Pallas, Juan Antonio García
Nov 9, 2017·Molecular Plant Pathology·Hongying ShanBernardo Rodamilans
Oct 10, 2013·Molecular Plant Pathology·Juan Antonio GarcíaThierry Candresse
Jul 13, 2019·Annual Review of Virology·Hongguang Cui, Aiming Wang
Jun 6, 2018·Frontiers in Plant Science·Bernardo RodamilansJuan Antonio García
Aug 28, 2019·Molecular Plant-microbe Interactions : MPMI·Bernardo RodamilansJuan Antonio García
Feb 13, 2020·Plants·Kristin WidyasariKook-Hyung Kim

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