Host sphingomyelin increases West Nile virus infection in vivo.

Journal of Lipid Research
Miguel A Martín-AcebesJuan-Carlos Saiz

Abstract

Flaviviruses, such as the dengue virus and the West Nile virus (WNV), are arthropod-borne viruses that represent a global health problem. The flavivirus lifecycle is intimately connected to cellular lipids. Among the lipids co-opted by flaviviruses, we have focused on SM, an important component of cellular membranes particularly enriched in the nervous system. After infection with the neurotropic WNV, mice deficient in acid sphingomyelinase (ASM), which accumulate high levels of SM in their tissues, displayed exacerbated infection. In addition, WNV multiplication was enhanced in cells from human patients with Niemann-Pick type A, a disease caused by a deficiency of ASM activity resulting in SM accumulation. Furthermore, the addition of SM to cultured cells also increased WNV infection, whereas treatment with pharmacological inhibitors of SM synthesis reduced WNV infection. Confocal microscopy analyses confirmed the association of SM with viral replication sites within infected cells. Our results unveil that SM metabolism regulates flavivirus infection in vivo and propose SM as a suitable target for antiviral design against WNV.

References

Feb 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·R O BradyD S Fredrickson
Feb 11, 1999·Neurochemical Research·C Rodriguez-Lafrasse, M T Vanier
Oct 3, 2001·Physiological Reviews·J C HolthuisG Van Meer
Dec 4, 2003·Journal of Virology·Bimmi ShresthaMichael S Diamond
Apr 22, 2004·FEMS Microbiology Letters·Pierre-Emmanuel CeccaldiPhilippe Despres
Jul 28, 2004·Biochemistry·Etsuko KiyokawaToshihide Kobayashi
Apr 21, 2005·The Journal of Biological Chemistry·Etsuko KiyokawaToshihide Kobayashi
Dec 24, 2005·Journal of Lipid Research·Mohammad Reza Hojjati, Xian-Cheng Jiang
Jan 13, 2006·Nature Chemical Biology·Hiroshi SakamotoMasayuki Sudoh
Jun 27, 2006·Journal of Neurovirology·Elizabeth A Hunsperger, John T Roehrig
Oct 20, 2006·Biochimica Et Biophysica Acta·Antonio DelgadoGemma Fabrias
Nov 17, 2007·Cell Host & Microbe·Jason M MackenzieRobert G Parton
Feb 6, 2008·The Journal of Infectious Diseases·Fumitake AmemiyaNobuyuki Enomoto
Feb 12, 2008·Lancet·E A Gould, T Solomon
Aug 5, 2008·Journal of Neurochemistry·Federica ScandroglioSandro Sonnino
Aug 22, 2008·Journal of Virology·Benno WölkCharles M Rice
Oct 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ching G NgDiane E Griffin
Apr 22, 2009·Cell Host & Microbe·Sonja WelschRalf Bartenschlager
Sep 10, 2010·Annual Review of Microbiology·Johan A den Boon, Paul Ahlquist
Sep 17, 2010·Journal of Virology·Leiyun WengTetsuya Toyoda
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicholas S HeatonGlenn Randall
Oct 6, 2010·Advances in Experimental Medicine and Biology·Christopher R GaultYusuf A Hannun
Nov 16, 2010·Cell Host & Microbe·Nicholas S Heaton, Glenn Randall
Nov 26, 2010·Journal of Virology·Angela Vázquez-CalvoMiguel A Martín-Acebes
Jan 11, 2011·Journal of Neurochemistry·Maria Dolores LedesmaEdward H Schuchman
Jan 14, 2011·The Journal of General Virology·Miguel A Martín-Acebes, Juan-Carlos Saiz
Jun 2, 2011·Cold Spring Harbor Perspectives in Biology·Maier Lorizate, Hans-Georg Kräusslich
Nov 22, 2011·Neurochemical Research·Rao Muralikrishna AdibhatlaA Gusain
Mar 30, 2012·PLoS Pathogens·Rushika PereraRichard J Kuhn
Jun 12, 2012·Current Opinion in Microbiology·Vineela ChukkapalliGlenn Randall
Oct 6, 2012·Current Opinion in Virology·George A Belov, Frank J M van Kuppeveld
Apr 12, 2012·World Journal of Virology·Miguel A Martín-Acebes, Juan-Carlos Saiz
Dec 25, 2013·PloS One·Emilie DonadieuMuriel Coulpier
Feb 4, 2014·Cell Death and Differentiation·E Gabandé-RodríguezM D Ledesma

❮ Previous
Next ❯

Citations

Nov 5, 2016·Progress in Lipid Research·Miguel A Martín-AcebesJuan-Carlos Saiz
Jun 28, 2018·Journal of Lipid Research·An NguyenMichael J O Wakelam
Dec 27, 2018·Cellular Microbiology·Alberto Fernández-OlivaCristina Risco
Apr 20, 2019·Emerging Microbes & Infections·Nereida Jiménez de OyaMiguel A Martín-Acebes
Oct 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takao SanakiAkihiko Sato
Dec 14, 2018·Journal of Virology·Gabrielle PastenkosAnthony V Nicola
Oct 1, 2019·Annual Review of Virology·Ellen Ketter, Glenn Randall
Jun 13, 2020·Nature Communications·Qian ChenNabila Jabrane-Ferrat
May 6, 2017·Nature Reviews. Drug Discovery·Veaceslav BoldescuChristian D Klein
Mar 14, 2019·Frontiers in Microbiology·Zhenlu ZhangXiaofeng Wang
May 20, 2020·Frontiers in Microbiology·Amani AudiHassan Zaraket
Oct 30, 2020·ELife·Anya J O'NealJoao Hf Pedra
Feb 9, 2021·Frontiers in Medicine·Ralf A Claus, Markus H Graeler
Apr 19, 2021·Virology·Adam J López-DenmanJason M Mackenzie
Apr 14, 2018·Chemical Reviews·Nicholas J BarrowsMariano A Garcia-Blanco
Nov 12, 2020·Journal of Proteome Research·Feifei ZhuKeping Chen
Aug 28, 2021·International Journal of Molecular Sciences·Bernadette Breiden, Konrad Sandhoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.