PMID: 9178267May 1, 1997Paper

Host urokinase-type plasminogen activator participates in the release of malaria merozoites from infected erythrocytes

Molecular and Biochemical Parasitology
E RoggwillerC Braun-Breton

Abstract

Malaria infection of red blood cells is associated with plasminogen activation. Surface immunofluorescence and immunoprecipitation experiments, using specific polyclonal and monoclonal antibodies raised against human urokinase, demonstrate that this activity is due to the binding of host urokinase-type plasminogen activator to the surface of erythrocytes infected by mature forms of Plasmodium falciparum malaria parasites. Depletion of urokinase from the culture medium leads to the inhibition of merozoite release and the accumulation of segmenter-infected erythrocytes; this inhibition is reversed by the addition of human single-chain or two-chain urokinase. These findings are consistent with host urokinase being involved in the process of merozoite release from the red blood cell.

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Citations

Jul 25, 2007·Bioinformatics·Matthew D DyerBruno W Sobral
Mar 21, 1998·Emerging Infectious Diseases·P J Rosenthal
Jan 8, 1999·Molecular and Biochemical Parasitology·P J RosenthalE F Plow
Apr 2, 2017·BMC Veterinary Research·Josipa KulešRenata Barić Rafaj
Sep 1, 2018·Bioscience Reports·Dolores A Ayón-NúñezJuan P Laclette
Oct 4, 2013·The Journal of Biological Chemistry·Lina TawkJean-Christophe Barale
Apr 4, 2021·International Journal of Molecular Sciences·Robert L Medcalf, Charithani B Keragala
May 19, 2000·Methods : a Companion to Methods in Enzymology·V A Ploplis, F J Castellino
Sep 25, 1998·Molecular and Biochemical Parasitology·E RoggwillerC Braun Breton

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