Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men

Journal of Psychosomatic Research
E C SuarezA L Hinderliter

Abstract

We examined the relation of Cook and Medley Hostility (Ho) scores to alpha- and beta-adrenergic receptor responsiveness to pharmacological agonists in 22 normotensive and 14 hypertensives (aged 18-34) white males, matched for age and body mass. alpha-Adrenergic receptor responsiveness was measured by the phenylephrine dose required to increase mean blood pressure by 25 mmHg (PD25). beta-Adrenergic responsiveness was measured by the isoproterenol dose needed to increase heart rate by 25 bpm (CD25), and to lower systemic vascular resistance by 40% (VD40). Relative to men with low Ho scores (< or = 21), men with high Ho scores (> or = 21) showed significantly reduced vascular beta 2-adrenergic receptor responsiveness (VD40). Moreover, the decreased vascular responsiveness was more pronounced in borderline hypertensive men with high Ho scores. Ho scores were also marginally significant in predicting cardiac beta 1- and beta 2-adrenergic receptor responsiveness, such that men with high Ho scores showed decreased responsiveness as indexed by a larger CD25. Vascular alpha 1-adrenergic responsiveness was not associated with hostility. These observations suggest that hostility, alone or in conjunction with BP status, is associated with ...Continue Reading

References

Jan 1, 1992·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·T W Smith
Jan 1, 1990·Psychophysiology·A SherwoodL J van Doornen
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Apr 1, 1995·Journal of the American College of Cardiology·D PoldermansA J Man in 't Veld

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Citations

Jun 11, 2002·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Catherine M StoneyLisa M Thornton
Aug 9, 2005·International Journal of Behavioral Medicine·Sherry D Broadwell, Kathleen C Light
Aug 20, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Misty A W HawkinsSungkyung Kim
Jan 29, 2010·Journal of Psychosomatic Research·Lena BrydonAndrew Steptoe
Jul 24, 2004·Psychosomatic Medicine·Andrew SherwoodAlan L Hinderliter
Apr 11, 2007·Psychosomatic Medicine·Petra H WirtzUlrike Ehlert

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