'Hot spots' of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus

Developmental Neuroscience
P KaldisTheo Wallimann

Abstract

Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence of a Mib-CK variant in avian cerebellum. This CK isoform was localized by immunofluorescence staining exclusively in the Purkinje neurons. The co-expression of this Mib-CK together with cytosolic muscle-type MM-CK, as observed in the same Purkinje neurons, may reflect the specific energy requirements associated with highly fluctuating Ca2+ levels (Ca2+ spiking) in these specialized neurons. Ubiquitous brain-type mitochondrial Mia-CK was found together with cytosolic BB-CK mainly in the glomeruli structures of the cerebellar granular layer. BB-CK, but much less so Mia-CK however, was also very prominent in Bergmann glial cells of the two mitochondrial Mi-CK isoenzymes in the chicken cerebellum is demonstrated. Other hot spots of CK localization were the granule and pyramidal cells of the hippocampus in rat. There, a developmental stage-dependent immunofluorescence staining, especially with antibodies against Mia-CK w...Continue Reading

Citations

Mar 3, 2009·Amino Acids·Bruno GualanoAntonio Herbert Lancha Junior
Mar 31, 2011·Amino Acids·Theo WallimannUwe Schlattner
Apr 2, 2004·Neurobiology of Disease·Peter KlivenyiM Flint Beal
Feb 13, 2001·Brain Research. Molecular Brain Research·O BraissantC Bachmann
Jan 16, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Oscar Ramírez, Esperanza Jiménez
Dec 14, 1999·Protein Science : a Publication of the Protein Society·M EderK Fritz-Wolf
May 24, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·L S Nersesova
Feb 22, 2001·Annual Review of Physiology·W R Ellington
Dec 3, 2013·The British Journal of Nutrition·Marina Yazigi SolisBruno Gualano
Oct 2, 2003·Expert Opinion on Investigational Drugs·Steven K Baker, Mark A Tarnopolsky
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A JacobsP B Barker
Apr 3, 2012·Neuroscience and Biobehavioral Reviews·Patricia J Allen
Nov 3, 2009·Neurobiology of Disease·Olivier BraissantHugues Henry
Mar 5, 2002·The Journal of Investigative Dermatology·Uwe SchlattnerTheo Wallimann
May 27, 2008·Brain Research Bulletin·Robert H AndresHans Rudolf Widmer
Feb 6, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Juan YangChen Huang
Aug 30, 2006·Brain Research·Elizabeth O'BrienIzuru Matsumoto
May 1, 1999·Experimental Neurology·R T MatthewsM F Beal
Nov 3, 2012·Neurobiology of Aging·Natalie M ZahrAdolf Pfefferbaum
Aug 26, 1998·Biochimica Et Biophysica Acta·M F Beal
Nov 15, 2016·Analytical Biochemistry·Veronika RackayovaOlivier Braissant
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C G Choi, J Frahm
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J Pouwels, J Frahm
May 26, 2007·Journal of Neuroscience Research·Angélique D DucrayHans Rudolf Widmer
Jan 13, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Carlos Alberto Abujabra Merege-FilhoBruno Gualano
May 1, 1997·The American Journal of Physiology·D HoltzmanF Jensen
May 10, 2019·Neurotoxicity Research·Eduardo Peil Marques, Angela T S Wyse
Aug 28, 2019·Biomolecules·Brent M KiousPerry F Renshaw
Oct 5, 2006·Experimental Biology and Medicine·I El GhaziI M Armitage
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Sep 14, 1999·The American Journal of Physiology·P DechentJ Frahm
Feb 14, 2021·Nutrients·Hamilton RoschelEric S. Rawson
Feb 24, 2021·Journal of Neurochemistry·Gustavo C FerreiraMary C McKenna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.