Hot topic: using a stearoyl-CoA desaturase transgene to alter milk fatty acid composition

Journal of Dairy Science
W A RehJ D Murray

Abstract

Stearoyl-CoA desaturase enzyme converts specific medium- and long-chain saturated fatty acids to their monounsaturated form. Transgenic goats expressing a bovine beta-lactoglobulin promoter-rat stearoyl-CoA desaturase cDNA construct in mammary gland epithelial cells were produced by pronuclear microinjection. The fatty acid composition of milk from 4 female transgenic founders was analyzed on d 7, 14, and 30 of their first lactation. In 2 animals, the expression of the transgene changed the overall fatty acid composition of the resulting milk fat to a less saturated and more monounsaturated fatty acid profile at d 7 of lactation; however, this effect diminished by d 30. In addition, one animal had an increased proportion of the rumen-derived monounsaturated fatty acid C18:1 trans11 converted by stearoyl-CoA desaturase to the conjugated linoleic acid isomer C18:2 cis9 trans11. Milk that has higher proportions of monounsaturated fatty acids and conjugated linoleic acid may have benefits for human cardiovascular health.

References

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Citations

May 19, 2011·Yi chuan = Hereditas·Da-Wei YuWei-Hua DU
Feb 13, 2016·The Journal of Dairy Research·C Bruce A WhitelawChris Proudfoot
Dec 17, 2014·Animal : an International Journal of Animal Bioscience·S ŚwiątkiewiczD Józefiak
Nov 12, 2014·Annual Review of Animal Biosciences·Lydia C GarasElizabeth A Maga
Sep 10, 2005·Trends in Biotechnology·Elizabeth A Maga
Feb 5, 2008·Comparative Immunology, Microbiology and Infectious Diseases·G Laible
Apr 5, 2005·Nature Biotechnology·Robert J WallHarold W Hawk
Nov 17, 2006·Reproduction, Nutrition, Development·Eric SolerLouis-Marie Houdebine
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Oct 26, 2005·Transgenic Research·David M DonovanRobert J Wall
Jan 17, 2019·Journal, Genetic Engineering & Biotechnology·Mohamed S HassananeWei Shen
Mar 17, 2010·Journal of Animal Science·S C FahrenkrugB P Glenn
Jun 28, 2011·Journal of Animal Science·H NiemannG Flachowsky
Apr 25, 2012·Transgenic Research·Laurent BoulangerJean-Luc Vilotte
Sep 26, 2019·Frontiers in Genetics·Peter KaldsYulin Chen
Aug 24, 2007·Reproduction, Fertility, and Development·Heiner Niemann, Wilfried A Kues
Oct 21, 2017·Reproduction in Domestic Animals = Zuchthygiene·I Lamas-ToranzoP Bermejo-Álvarez
Dec 6, 2018·Nature Reviews. Genetics·Michel GeorgesBen Hayes
Nov 14, 2020·Annual Review of Animal Biosciences·Alison L Van EenennaamDavid Zilberman

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