Hot water extracts of Chlorella vulgaris improve immune function in protein-deficient weanling mice and immune cells

Immunopharmacology and Immunotoxicology
Hyo-Jin AnHyung-Min Kim

Abstract

The objective of this study was to investigate the effects of hot water extracts of Chlorella vulgaris (CVE) on a deteriorated immune function through utilization of a protein-energy malnutrition (PEM) diet. Unicellular algae, C. vulgaris, were used as biological response modifier. PEM is associated with decreased host immune defense. Male C57BL/6J mice, initially four weeks old, were fed for 8 days with standard diet or a PEM diet. Mice in the PEM diet group were orally administered 0.1 g/kg and 0.15 g/kg of CVE for the following week. Nutritional parameters such as the total protein, albumin, glucose, and interferon γ (IFN-γ) were increased in blood serum of the CVE-treated group compared with the non-treated group. The mononuclear cell numbers from spleen, superficial, and mesenteric lymph node were reduced in mice fed with PEM diet, but numbers from the spleen and superficial lymph node were increased by the CVE (0.1 and 0.15 g/kg) treatment. We also investigated the effect of CVE on the production of cytokines in human T-cell line, MOLT-4 cells, and primary cultured splenocytes. The CVE treatment significantly increased the production of both interleukin (IL)-2 and IL-4 compared with the media control, but did not affect t...Continue Reading

References

Dec 16, 1992·Biochimica Et Biophysica Acta·Y MinamiT Taniguchi
Jan 1, 1990·Immunopharmacology and Immunotoxicology·K TanakaK Nomoto
Jan 1, 1987·Advances in Immunology·D F Jelinek, P E Lipsky
Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·K TanakaK Nomoto
Jun 1, 1996·Current Opinion in Immunology·L L Carter, R W Dutton
Jun 1, 1997·Cytokine & Growth Factor Reviews·A MackensenR Mertelsmann
Jul 17, 1999·International Journal of Immunopharmacology·T HasegawaY Yasunobu
Nov 25, 2000·International Journal of Immunopharmacology·T HasegawaY Yoshikai
Jan 11, 2001·Pharmacology & Therapeutics·L Cohn, A Ray
Dec 12, 2001·Clinical and Experimental Immunology·O NájeraR Ortiz
Mar 9, 2002·Advances in Cancer Research·Angus G Dalgleish, Ken J O'Byrne
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·Robin StephensDavid D Chaplin
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Edgar Vásquez-GaribayBarbara Vizmanos-Lamotte
Jul 27, 2002·European Journal of Clinical Nutrition·R K Chandra
Oct 12, 2002·Immunopharmacology and Immunotoxicology·Mary L S QueirozLeonilda M B Santos
Oct 18, 2002·Cancer Immunology, Immunotherapy : CII·Keith DredgeAngus G Dalgleish
Jan 7, 2003·The Journal of Nutrition·Gerald T Keusch
Jan 28, 2005·Experimental Biology and Medicine·Tirang R Neyestani, Bill Woodward

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Citations

Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Nien-Tzu ChouChing-Huai Ko
Sep 17, 2013·Nutrition·Na-Ra HanHyun-Ja Jeong
Feb 2, 2019·Animals : an Open Access Journal From MDPI·Maria Giovanna CilibertiMariangela Caroprese
Jun 18, 2016·Molecular Medicine Reports·Na-Rae KimHyun-Ja Jeong
Oct 13, 2020·Frontiers in Bioengineering and Biotechnology·Jian Yao NgPui Lai Rachel Ee

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