Hotspots of Transmission Driving the Local Human Immunodeficiency Virus Epidemic in the Cologne-Bonn Region, Germany.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Melanie StecherAntoine Chaillon

Abstract

Geographical allocation of interventions focusing on hotspots of human immunodeficiency virus (HIV) transmission has the potential to improve efficiency. We used phylogeographic analyses to identify hotspots of the HIV transmission in Cologne-Bonn, Germany. We included 714 HIV-1 infected individuals, followed up at the University Hospitals Cologne and Bonn. Distance-based molecular network analyses were performed to infer putative relationships. Characteristics of genetically linked individuals and assortativity (shared characteristics) were analyzed. Geospatial diffusion (ie, viral gene flow) was evaluated using a Slatkin-Maddison approach. Geospatial dispersal was determined by calculating the average distance between the residences of linked individuals (centroids of 3-digit zip code). In sum, 217/714 (30.4%) sequences had a putative genetic linkage, forming 77 clusters (size range: 2-8). Linked individuals were more likely to live in areas surrounding the city center (P = .043), <30 years of age (P = .009). and infected with HIV-1 subtype B (P = .002). Clustering individuals were nonassortative by area of residency (-.0026, P = .046). Geospatial analyses revealed a median distance between genetically linked individuals of 2...Continue Reading

Associated Clinical Trials

May 29, 2014·Dr. med. Jörg Janne Vehreschild

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Citations

Apr 7, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas C S MartinMartin Hoenigl
Mar 25, 2020·Frontiers of Medicine·Xiaoxu HanHong Shang
Mar 19, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Max J HassensteinStefanie Castell
Jan 10, 2020·Open Forum Infectious Diseases·Harald H KesslerMartin Hoenigl

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