House dust mite-induced sensitivity in mice

The Journal of Allergy and Clinical Immunology
K C ChengT J Yoo

Abstract

Sensitivity induced by house dust mite (HDM) extract in mice was investigated in this study. Sensitized B10.RIII mice (H-2r background) had T-cell proliferative responses to HDM extract in vitro and an HDM-specific IgE response. When mice were immunized by injection and intranasal inhalation with HDM extract, a histologic study showed eosinophils and mononuclear cell infiltration in the lung tissue and bronchial wall. Tcr alphabeta-positive cells were also found in the cell infiltration area of the lung lesions. In the control mice that were immunized by injection or intranasal inhalation (but not both), we did not observe cell accumulation in the lung tissue or in the bronchial wall. Epitope studies suggest that T cells recognize multiple epitopes. Molecular analysis of these HDM-specific T-cell hybridoma clones suggest that T-cell receptor use is restricted to members of the V alpha 8 and Vbeta 6 subfamilies.

References

Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DilworthW R Thomas
Jan 1, 1984·Clinical Immunology Reviews·D Y Leung, R S Geha
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L R WedderburnM J Owen

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Citations

May 5, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Soo Whan Kim, Sang Won Yeo
Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katherine E MensonMatthew E Poynter

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