Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats

Phytotherapy Research : PTR
Byoung Hoon YouYoung Hee Choi

Abstract

The synergistic activity of Houttuynia cordata ethanol extract (HCT) and metformin combination in diabetic rats has been previously reported, but the fundamental causes remain unsolved. Organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the liver and kidneys. Therefore, pharmacological activity and systemic exposure of metformin in HCT-metformin combination were determined from pharmacokinetic change and glucose-lowering activity using in vitro HEK-293 cells expressing human OCTs or human MATEs and in vivo rats. HCT inhibited human OCT2 and human MATE1-mediated metformin transports in vitro. In in vivo rats, treatment with HCT and metformin for 28 days in rats (28MH rats) reduced the rat Oct2-mediated renal excretion of metformin and thereby the increased systemic exposure of metformin compared with only metformin-treated rats for 28 days (28M rats). In 28MH rats, rat Oct1-mediated metformin uptake into the liver was enhanced, leading to an improved glucose-lowering effect without hypoglycaemia compared with 28M rats. There was no impairment of renal function in HCT and metformin treatments. These results suggest that HCT-metformin combination therapy is applicable in te...Continue Reading

References

Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·George B KudoloJanet Blodgett
Aug 29, 2006·Journal of Pharmaceutical Sciences·Young H ChoiMyung G Lee
May 4, 2007·The Journal of Clinical Investigation·Yan ShuKathleen M Giacomini
Jan 19, 2011·Clinical Pharmacokinetics·Garry G GrahamKenneth M Williams
Mar 13, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J William HigginsMaciej J Zamek-Gliszczynski
Jun 23, 2012·Pharmacogenetics and Genomics·Li GongTeri E Klein
Dec 27, 2012·Clinical Pharmacology and Therapeutics·S L StockerK M Giacomini
Oct 1, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P K PrabhakarMukesh Doble
Mar 7, 2014·Pharmacognosy Reviews·Manish KumarS Hemalatha
Sep 23, 2014·Journal of Agricultural and Food Chemistry·Ji Hae LeeSung-Joon Lee
Sep 25, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Muhammad Amin, Naeti Suksomboon
Dec 9, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yan-rong MaXin-an Wu
May 7, 2015·Clinical Pharmacokinetics·Tore Bjerregaard StageMette Marie Hougaard Christensen
Jul 2, 2015·Planta medica·José Luis RíosGuillermo R Schinella
Mar 29, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·H J BurtK Rowland-Yeo
Apr 20, 2016·Therapeutic Advances in Endocrinology and Metabolism·Marcus May, Christoph Schindler

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