How a calculated oxidative stress can yield multiple therapeutic effects

Free Radical Research
Velio Bocci

Abstract

It is proposed to discuss how ozonetherapy acts on patients affected by vascular and degenerative diseases. Ozone is a strong oxidant but, if used in small dosages on human blood ex vivo, acts as an acceptable stressor. By instantly reacting with PUFA bound to albumin, ozone is entirely consumed but generates two messengers acting in an early and in a late phase: the former is due to hydrogen peroxide, which triggers biochemical pathways on blood cells and the latter is due to alkenals which are infused into the donor patient. After undergoing a partial catabolism, alkenals enter into a great number of body's cells, where they react with Nrf2-Keap1 protein: the transfer of activated Nrf2 into the nucleus and its binding to antioxidant response element (ARE) is the crucial event able to upregulate the synthesis of antioxidant proteins, phase II enzymes and HO-1. With the progress of ozonetherapy, these protective enzymes are able to reverse the oxidative stress induced by chronic inflammation. Consequently, the repetition of graduated stresses induces a multiform adaptive response able to block the progress of the disease and to improve the quality of life.

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Citations

Mar 26, 2014·Diabetes & Metabolic Syndrome·Velio BocciValter Travagli
Nov 7, 2015·Neurotoxicology·Xiaoyi LiJun Chen
Dec 21, 2012·Toxicology and Applied Pharmacology·Alessandra PecorelliGiuseppe Valacchi
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Jun 20, 2018·Clinical Hemorheology and Microcirculation·Ismail Hakki AkbudakMelek Bor-Kucukatay
Sep 2, 2018·The Science of the Total Environment·Evgenios AgathokleousEdward J Calabrese
Jan 27, 2020·Mechanisms of Ageing and Development·Catia ScassellatiCristina Geroldi
Jan 22, 2021·International Immunopharmacology·Morteza IzadiAmir Hosein Ghazale
May 23, 2021·Reproduction in Domestic Animals = Zuchthygiene·Jair Camargo FerreiraCezinande de Meira

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