We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonally cold days (low temperatures and short day lengths). The enhanced splicing of this intron at low temperatures advances the steady state phases of the per mRNA and protein cycles, events that significantly contribute to the preferential daytime activity of flies on cold days. Because the accumulation of PER is also dependent on the photosensitive TIMELESS (TIM) protein, long photoperiods partially counteract the cold-induced advances in the oscillatory mechanism by delaying the daily increases in the levels of TIM. Our findings also indicate that there is a temperature-dependent switch in the molecular logic governing cycles in per mRNA levels.
Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginal Drosophila melanogaster
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL
Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript
Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells
Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells.
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system
Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
per mRNA cycling is locked to lights-off under photoperiodic conditions that support circadian feedback loop function.
The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants
Thermally regulated translational control of FRQ mediates aspects of temperature responses in the neurospora circadian clock
Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript
Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception
Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster
Two alternatively spliced transcripts from the Drosophila period gene rescue rhythms having different molecular and behavioral characteristics.
The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex
Effect of photoperiod on clock gene expression and subcellular distribution of PERIOD in the circadian clock neurons of the blow fly Protophormia terraenovae
Bactrocera tryoni and closely related pest tephritids--molecular analysis and prospects for transgenic control strategies
Environmentally-induced modulations of developmental rates do not affect the selection-mediated changes in pre-adult development time of fruit flies Drosophila melanogaster
Short-day and long-day expression patterns of genes involved in the flesh fly clock mechanism: period, timeless, cycle and cryptochrome
The circadian clock regulated RNA-binding protein AtGRP7 autoregulates its expression by influencing alternative splicing of its own pre-mRNA
Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration
Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female
Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs
The lateral and dorsal neurons of Drosophila melanogaster: new insights about their morphology and function
Circadian control of messenger RNA stability. Association with a sequence-specific messenger RNA decay pathway
CIRCADIAN CLOCK ASSOCIATED1 transcript stability and the entrainment of the circadian clock in Arabidopsis
Splicing of the period gene 3'-terminal intron is regulated by light, circadian clock factors, and phospholipase C.
Selective entrainment of the Drosophila circadian clock to daily gradients in environmental temperature
Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides
Natural allelic variation in the temperature-compensation mechanisms of the Arabidopsis thaliana circadian clock
Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C
Brain developing: Influences & Outcomes
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