How adhesion forms the early mammalian embryo

Current Topics in Developmental Biology
Melanie D White, Nicolas Plachta

Abstract

The early mouse embryo is an excellent system to study how a small group of initially rounded cells start to change shape and establish the first forms of adhesion-based cell-cell interactions in mammals in vivo. In addition to its critical role in the structural integrity of the embryo, we discuss here how adhesion is important to regulate cell polarity and cell fate. Recent evidence suggests that adherens junctions participate in signaling pathways by localizing key proteins to subcellular microdomains. E-cadherin has been identified as the main player required for the establishment of adhesion but other mechanisms involving additional proteins or physical forces acting in the embryo may also contribute. Application of new technologies that enable high-resolution quantitative imaging of adhesion protein dynamics and measurements of biomechanical forces will provide a greater understanding of how adhesion patterns the early mammalian embryo.

Citations

Sep 5, 2015·F1000Research·Olga Klezovitch, Valeri Vasioukhin
Oct 11, 2017·PloS One·Paula Quintero-RonderosPaul Laissue
Jul 25, 2019·Obstetrics & Gynecology Science·Chang-Zhu PeiKwang-Hyun Baek
Jul 1, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paula Quintero-Ronderos, Paul Laissue
Dec 3, 2016·Journal of Cell Science·Jeroen Eyckmans, Christopher S Chen
Oct 5, 2019·Biochemical and Biophysical Research Communications·Kouichi TachibanaJun Miyake
Aug 28, 2021·Cells·Paola RebuzziniSilvia Garagna
Sep 30, 2021·Cell and Tissue Research·Ecem YildirimAylin Yaba

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