How alternative splicing affects membrane-trafficking dynamics

Journal of Cell Science
R Eric BlueJimena Giudice

Abstract

The cell biology field has outstanding working knowledge of the fundamentals of membrane-trafficking pathways, which are of critical importance in health and disease. Current challenges include understanding how trafficking pathways are fine-tuned for specialized tissue functions in vivo and during development. In parallel, the ENCODE project and numerous genetic studies have revealed that alternative splicing regulates gene expression in tissues and throughout development at a post-transcriptional level. This Review summarizes recent discoveries demonstrating that alternative splicing affects tissue specialization and membrane-trafficking proteins during development, and examines how this regulation is altered in human disease. We first discuss how alternative splicing of clathrin, SNAREs and BAR-domain proteins influences endocytosis, secretion and membrane dynamics, respectively. We then focus on the role of RNA-binding proteins in the regulation of splicing of membrane-trafficking proteins in health and disease. Overall, our aim is to comprehensively summarize how trafficking is molecularly influenced by alternative splicing and identify future directions centered on its physiological relevance.

References

Jun 26, 1995·Biochemical and Biophysical Research Communications·K IbarakiT Abe
Apr 14, 1995·Science·S MaignanA Ducruix
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·I C BarkM C Wilson
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·T A CookM A McNiven
Sep 1, 1996·Nature Genetics·D SakamuroG C Prendergast
Feb 24, 1997·Biochemical and Biophysical Research Communications·F Mollinedo, P A Lazo
Jan 27, 1998·The Journal of Biological Chemistry·H OgawaR Hosono
Sep 3, 1998·Molecular Biology of the Cell·H CaoM A McNiven
May 18, 1999·Biochemical and Biophysical Research Communications·K Vogel, P A Roche
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·K GeG C Prendergast
Jul 11, 2001·Biochemical and Biophysical Research Communications·A ShuklaR Dahl
Nov 1, 2001·Annual Review of Cell and Developmental Biology·F M BrodskyD E Wakeham
Jun 11, 2002·Biochemical and Biophysical Research Communications·Lin WangSeth Corey
Aug 17, 2002·Science·Eunkyung LeePietro De Camilli
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Louise ChangAlan R Saltiel
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sonia Martinez-ArcaThierry Galli
Nov 15, 2003·Science·Jernej UleRobert B Darnell
Apr 29, 2004·American Journal of Human Genetics·R S SavkurJ W Day
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christina BarkMichael C Wilson
Oct 16, 2004·The EMBO Journal·Chie KojimaHisataka Sabe
Nov 18, 2004·The Journal of Biological Chemistry·Warunee DansithongSita Reddy
Jul 26, 2005·Nature Genetics·Jernej UleRobert B Darnell
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Sep 21, 2006·Journal of Cell Science·Meghan E Maurer, Jonathan A Cooper
May 29, 2007·Molecular and Cellular Neurosciences·René L VidalAndrés Couve
Jul 17, 2007·Current Opinion in Cell Biology·Ernst J Ungewickell, Lars Hinrichsen

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Citations

Jan 25, 2020·Scientific Reports·Juan A Ferrer-BonsomsAngel Rubio
Mar 20, 2020·International Journal of Molecular Sciences·Ken-Ichi FujitaSeiji Masuda
Aug 20, 2019·Applied Microbiology and Biotechnology·Louise SchelletterRaimund Hoffrogge
Jan 21, 2021·Nature Communications·Anoushka JoglekarHagen U Tilgner
Dec 17, 2020·International Journal of Molecular Sciences·Juan F García-Moreno, Luísa Romão
Mar 18, 2020·Biochemical and Biophysical Research Communications·Ho-Hyung Woo, Setsuko K Chambers

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