PMID: 9173101May 1, 1997Paper

How amino acids control the binding of Cu(II) ions to DNA (II): effect of basic amino acid residues and the chirality on the orientation of the complexes

Journal of Inorganic Biochemistry
Makoto ChikiraH Shindo

Abstract

The binding structures of bis-lysine and bis-arginine complexes of copper(II) on highly oriented DNA fibers have been investigated by ESR spectroscopy. These complexes bind to DNA in two different modes; species A in one mode has a planar coordination structure as in solution, and species B in the other mode has a distorted planar structure on the DNA. The relative amount of A and B changes with the conformation of the DNA, as well as with the type and chirality of the amino acids. Arginine forms A more than lysine. On A-form DNA fibers, A for L-lysine and L-arginine complexes are bound with the angle theta = 45 degrees between the g// axis and the DNA helical axis, while A and B for the D-isomers are almost randomly oriented. L-arginine fixes the orientation of A on A-form DNA fibers more firmly than L-lysine. On B-form DNA fibers, the orientation of the complexes is modulated dynamically, and the g// axes have a tendency to be reoriented along the fiber axis by the conformational change of the DNA from A- to B-form at room temperature. The D-arginine complex on B-form DNA is peculiar in that it rotates ore freely than the other complexes at room temperature and shows only the A at low temperature.

References

Feb 1, 1991·The Biochemical Journal·O I AruomaM Dizdaroglu
Mar 1, 1990·Chemical Research in Toxicology·S InoueS Kawanishi
Jan 1, 1987·Free Radical Biology & Medicine·R Stoewe, W A Prütz
Apr 1, 1995·Protein Engineering·M SuzukiN Yagi

❮ Previous
Next ❯

Citations

Feb 24, 2001·Journal of Inorganic Biochemistry·R NaganeE C Long
Feb 11, 2003·Journal of Inorganic Biochemistry·Ryoichi NaganeMakoto Chikira
Mar 7, 2009·The Journal of Biological Chemistry·Irmgard ParisJuan Segura-Aguilar
Jul 28, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hoi-Ling SengChew-Hee Ng
Jan 11, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Chew Hee NgMakoto Chikira
Jan 16, 2003·Inorganic Chemistry·M ChikiraD H Petering

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.