PMID: 11336836May 5, 2001Paper

How and when are substrates selected for type III secretion?

Trends in Microbiology
P Aldridge, K T Hughes

Abstract

Many Gram-negative bacteria use type III secretion systems to secrete virulence factors as well as the structural components of the flagellum. Some bacterial secretion systems use a secretion signal contained in the amino acid sequence of the secreted substrate. However, substrates of type III systems lack a single, defined secretion signal. There is evidence for the existence of three independent secretion signals - the 5' region of the mRNA, the amino terminus of the substrate and the ability of a secretion chaperone to bind the substrate before secretion - that direct substrates for secretion through the type III pathways. One or more of these signals might be used for a given substrate. A recent study of flagellar assembly presented evidence for a role of translation in the type III secretion mechanism. We present a unifying model for type III secretion that can be applied to flagellar assembly, needle assembly and the secretion of virulence factors. The potential role of translation in regulating the timing of substrate secretion is also discussed.

References

Apr 29, 2000·Trends in Microbiology·J C Bennett, C Hughes
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Aug 31, 2000·Cell·J E KarlinseyK T Hughes
Jan 3, 2001·Molecular Microbiology·S A LloydH Wolf-Watz

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Citations

Aug 10, 2006·Archives of Microbiology·Corinna Weber-SparenbergHeinrich Jung
Jun 12, 2003·FEMS Microbiology Letters·Mark J PallenKlaus Fütterer
Aug 14, 2003·Trends in Microbiology·Nikhil A Thomas, B Brett Finlay
Oct 9, 2001·Trends in Plant Science·T Lahaye, U Bonas
Mar 5, 2003·Current Opinion in Microbiology·Claude ParsotAnne-Laure Page
Apr 6, 2002·Current Opinion in Microbiology·Phillip Aldridge, Kelly T Hughes
Jan 1, 2002·Molecular Plant Pathology·Sabine MoorePaul Tudzynski
May 15, 2004·Molecular Plant-microbe Interactions : MPMI·Libo ShanXiaoyan Tang
Oct 27, 2004·Infection and Immunity·Kwon-Sam ParkTakeshi Honda
Jun 3, 2006·Journal of Bacteriology·Phillip AldridgeKelly T Hughes
Dec 14, 2004·Microbiology and Molecular Biology Reviews : MMBR·Ian R HendersonDlawer Ala'Aldeen
Mar 25, 2010·BMC Microbiology·David GoudenègeFrédérique Barloy-Hubler
Oct 29, 2010·Human Genomics and Proteomics : HGP·Alessio SquassinaMaria Del Zompo
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chunhao LiNyles W Charon
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wanyin DengB Brett Finlay
Mar 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joanne ThomasColin Hughes
Jun 14, 2008·Biomedical and Environmental Sciences : BES·Da-Kang ShenBenoit Polack
May 1, 2003·Molecular Plant Pathology·Asha M Brunings, Dean W Gabriel
Nov 28, 2002·Seminars in Perinatology·Marc D Foca
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Apr 6, 2005·FEMS Microbiology Reviews·Mark J PallenChristopher M Bailey
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Jul 2, 2015·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Sue PattersonIan Williams
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Mar 2, 2018·Frontiers in Microbiology·Mickaël DesvauxPascale Serror

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