How and why does tomato accumulate a large amount of GABA in the fruit?

Frontiers in Plant Science
Mariko Takayama, Hiroshi Ezura

Abstract

Gamma-aminobutyric acid (GABA) has received much attention as a health-promoting functional compound, and several GABA-enriched foods have been commercialized. In higher plants, GABA is primarily metabolized via a short pathway called the GABA shunt. The GABA shunt bypasses two steps (the oxidation of α-ketoglutarate to succinate) of the tricarboxylic acid (TCA) cycle via reactions catalyzed by three enzymes: glutamate decarboxylase, GABA transaminase, and succinic semialdehyde dehydrogenase. The GABA shunt plays a major role in primary carbon and nitrogen metabolism and is an integral part of the TCA cycle under stress and non-stress conditions. Tomato is one of the major crops that accumulate a relatively high level of GABA in its fruits. The GABA levels in tomato fruits dramatically change during fruit development; the GABA levels increase from flowering to the mature green stage and then rapidly decrease during the ripening stage. Although GABA constitutes up to 50% of the free amino acids at the mature green stage, the molecular mechanism of GABA accumulation and the physiological function of GABA during tomato fruit development remain unclear. In this review, we summarize recent studies of GABA accumulation in tomato frui...Continue Reading

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Citations

Jun 23, 2016·Metabolomics : Official Journal of the Metabolomic Society·Tahira FatimaAutar K Mattoo
Nov 28, 2018·The Plant Journal : for Cell and Molecular Biology·Guoping WangWenyi Wang
Jan 17, 2019·Critical Reviews in Biotechnology·Aili BaoLam-Son Phan Tran
Feb 3, 2019·Applied and Environmental Microbiology·Sophia Jiyuan ZhangLuc De Vuyst
May 12, 2019·Metabolites·Martine Lemaire-ChamleyAnnick Moing
Jan 28, 2020·The Plant Journal : for Cell and Molecular Biology·Sanu ShameerLee J Sweetlove
Oct 6, 2019·Scientific Reports·Daniela PontiggiaBenedetta Mattei
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Mar 7, 2020·Frontiers in Plant Science·Stefano BrizzolaraPietro Tonutti
Apr 5, 2018·Frontiers in Plant Science·Francy L García-AriasVictor M Núñez Zarantes
Jan 18, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tessa H de BieMichiel G J Balvers
Sep 28, 2020·Journal of Biotechnology·Mujtaba Aamir BhatArif Tasleem Jan
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Apr 10, 2019·Journal of Agricultural and Food Chemistry·Stefano BrizzolaraPietro Tonutti

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Methods Mentioned

BETA
transgenic
environmental stresses

Software Mentioned

Tom
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