Mar 26, 2010

How are T(H)2-type immune responses initiated and amplified?

Nature Reviews. Immunology
William E Paul, Jinfang Zhu

Abstract

CD4(+) T helper (T(H)) cells have crucial roles in orchestrating adaptive immune responses. T(H)2 cells control immunity to extracellular parasites and all forms of allergic inflammatory responses. Although we understand the initiation of the T(H)2-type response in tissue culture in great detail, much less is known about T(H)2 cell induction in vivo. Here we discuss the involvement of allergen- and parasite product-mediated activation of epithelial cells, basophils and dendritic cells and the functions of the cytokines interleukin-4 (IL-4), IL-25, IL-33 and thymic stromal lymphopoietin in the initiation and amplification of T(H)2-type immune responses in vivo.

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  • Citations96

References

Mentioned in this Paper

TSLP protein, human
Immune Response
C19orf10 gene
Basophils
Extracellular
SpecimenType - Basophils
Squamous Transitional Epithelial Cell Count
Transcription Initiation
Allergens
Gene Amplification Technique

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