How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
N M Ter HaarS J Vastert

Abstract

IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.

Citations

Dec 15, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Liza J McCann, Christian M Hedrich
Jul 3, 2021·Journal of Clinical Medicine·Stéphane Mitrovic, Bruno Fautrel
Aug 4, 2021·Nature Reviews. Rheumatology·Zoltán SzekaneczGabriella Szűcs
Sep 22, 2021·European Journal of Medical Research·Larissa Valor-MéndezJürgen Rech

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