How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Antonin Bukovsky

Abstract

At the beginning of the last century, reproductive biologists have discussed whether in mammalian species the fetal oocytes persist or are replaced by neo-oogenesis during adulthood. Currently the prevailing view is that neo-oogenesis is functional in lower vertebrates but not in mammalian species. However, contrary to the evolutionary rules, this suggests that females of lower vertebrates have a better opportunity to provide healthy offspring compared to mammals with oocytes subjected to environmental threats for up to several decades. During the last 15 years, a new effort has been made to determine whether the oocyte pool in adult mammals is renewed as well. Most recently, Ji Wu and colleagues reported a production of offspring from female germline stem cells derived from neonatal and adult mouse ovaries. This indicates that both neonatal and adult mouse ovaries carry stem cells capable of producing functional oocytes. However, it is unclear whether neo-oogenesis from ovarian somatic stem cells is physiologically involved in follicular renewal and why menopause occurs. Here we review observations that indicate an involvement of immunoregulation in physiological neo-oogenesis and follicular renewal from ovarian stem cells dur...Continue Reading

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Citations

Dec 19, 2012·Reproductive Biology and Endocrinology : RB&E·Onder CelikBulent Tiras
Mar 20, 2013·BioMed Research International·Deepa BhartiyaSandhya Anand
Apr 19, 2012·American Journal of Reproductive Immunology : AJRI·Stanimir KyurkchievUdo R Markert
Nov 21, 2012·Journal of Ovarian Research·Michail VarrasNikolaos Paparisteidis
Apr 9, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Corrina J Horan, Suzannah A Williams
Jun 30, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Antonin Bukovsky
Oct 2, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Deepa Bhartiya, Jarnail Singh

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