How can genetic diagnosis inform the decision of when to operate?

Journal of Visualized Surgery
Maral Ouzounian, Scott A LeMaire

Abstract

Genetic discovery for heritable thoracic aortic disease (HTAD) has been progressing at a brisk pace. Surgical management of thoracic aortic aneurysms and dissections has become more personalized, with genetic factors increasingly informing the decision of when to operate on patients. An improved understanding of genotype-phenotype correlations in patients with HTAD will ultimately lead to gene- and mutation-specific recommendations for surgical repair. Until more robust data from larger cohorts can inform our decisions, patients with HTAD should be seen by an aortic specialist for a tailored approach to elective surgical repair.

Citations

May 19, 2020·Journal of the American Heart Association·Vivek PatelHani Jneid
Jul 28, 2020·The Journal of Thoracic and Cardiovascular Surgery·Ashley Dawson, Scott A LeMaire

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

© 2022 Meta ULC. All rights reserved