How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis

Trials
Laura FlightDaniel Hind

Abstract

Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite research budgets and accurate decision-making are priorities for healthcare providers around the world. The methods of health economics, which aim to maximise the health gained for money spent, could be incorporated into the design and analysis of adaptive clinical trials to make them more efficient. We aimed to understand the perspectives of stakeholders in health technology assessments to inform recommendations for the use of health economics in adaptive clinical trials. A qualitative study explored the attitudes of key stakeholders-including researchers, decision-makers and members of the public-towards the use of health economics in the design and analysis of adaptive clinical trials. Data were collected using interviews and focus groups (29 participants). A framework analysis was used to identify themes in the transcripts. It was considered that answering the clinical research question should be the priority in a clinical trial, notwithstanding the importance of cost-effectiveness for decision-making. Concerns raised ...Continue Reading

References

Mar 1, 1992·Journal of Medical Ethics·A Williams
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A H Briggs, A M Gray
Dec 1, 2000·BMJ : British Medical Journal·A Briggs
Sep 23, 2003·Health Technology Assessment : HTA·J ChilcottP Tappenden
Apr 8, 2004·Statistical Methods in Medical Research·John CookJoseph F Heyse
Apr 15, 2004·Drug Discovery Today·Peter Bauer, Werner Brannath
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Deborah Ashby, Say-Beng Tan
Sep 18, 2007·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Allison TongJonathan Craig
Feb 29, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F TrottaG Tafuri
May 6, 2008·Orphanet Journal of Rare Diseases·Shein-Chung Chow, Mark Chang
Oct 13, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Bas Groot KoerkampM G Myriam Hunink
Mar 15, 2011·BMC Medical Research Methodology·Benedicte Carlsen, Claire Glenton
Jun 2, 2012·Journal of Biopharmaceutical Statistics·Shein-Chung ChowMin Lin
Dec 13, 2012·Clinical Trials : Journal of the Society for Clinical Trials·William HollingworthChris Metcalfe
Sep 21, 2013·BMC Medical Research Methodology·Nicola K GaleSabi Redwood
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·C Daniel MullinsPaul Wicks
Aug 3, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Haitham W TuffahaPaul A Scuffham
Mar 27, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Mark StrongPenny Breeze
Mar 31, 2015·International Journal of Technology Assessment in Health Care·Syed MohiuddinKatherine Payne
May 3, 2015·BMC Medical Ethics·Laurie J LegockiMichael D Fetters
Feb 15, 2018·BMJ Open·Laura E BothwellAaron S Kesselheim
Apr 13, 2019·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Laura FlightSusan Todd
Apr 17, 2020·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anna HeathHawre Jalal
Jun 17, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Natalia KunstUNKNOWN Collaborative Network for Value of Information

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