How can immunology contribute to the control of tuberculosis?

Nature Reviews. Immunology
Stefan H E Kaufmann

Abstract

Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the rise, and Mycobacterium tuberculosis infection is often associated with human immunodeficiency virus infection. Satisfactory control of tuberculosis can only be achieved using a highly efficacious vaccine. Tuberculosis is particularly challenging for the immune system. The intracellular location of the pathogen shields it from antibodies, and a variety of T-cell subpopulations must be activated to challenge the bacterium's resistance to antibacterial defence mechanisms. A clear understanding of the immune responses that control the pathogen will be important for achieving optimal immunity, and information provided by functional genome analysis of M. tuberculosis will be vital in the design of a future vaccine.

Associated Clinical Trials

Jul 1, 2010·Dr. S. Subash Babu

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L FlynnB R Bloom
Mar 1, 1989·Reviews of Infectious Diseases·P E Fine
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HorwitzG Harth
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·P J MurrayR A Young
Apr 1, 1996·Infection and Immunity·Y LinP F Barnes
Mar 1, 1996·Nature Medicine·I GuleriaB R Bloom
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·S H Kaufmann
Aug 1, 1996·Nature Medicine·R E TasconD B Lowrie
Aug 1, 1996·Nature Medicine·K HuygenJ B Ulmer
Mar 1, 1996·Infection·H M HasselhornF W Tiller
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Aug 22, 1997·Science·J S SchoreyE J Brown
Mar 20, 1998·Infection·F J Miras-ParraJ de la Higuera Torres-Puchol
Apr 7, 1998·Infection and Immunity·J D Ernst
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J HessS H Kaufmann
Jun 13, 1998·The Journal of Experimental Medicine·D M LewinsohnK H Grabstein
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y YuanC E Barry
Dec 10, 1998·Nature Medicine·S L HoffmanJ C Venter
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·R TeitelbaumB R Bloom
Jan 26, 1999·Advances in Immunology·U E SchaibleS H Kaufmann
Mar 19, 1999·Trends in Microbiology·S H Kaufmann
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E A RichZ Toossi
Jun 3, 1999·The Journal of Infectious Diseases·S I Behr-PerstS H Kaufmann
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
Jun 22, 1999·The Journal of Experimental Medicine·S M BeharM B Brenner
Jul 27, 1999·Nature·D B LowrieC L Silva
Oct 8, 1999·Immunity·U SteinhoffS H Kaufmann
Oct 16, 1999·The New England Journal of Medicine·A van RieP D van Helden
Oct 26, 1999·Immunobiology·U Zügel, S H Kaufmann
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M WilsonG K Schoolnik

❮ Previous
Next ❯

Citations

Feb 24, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marc JacobsenStefan H E Kaufmann
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Jul 19, 2013·Seminars in Immunopathology·Evelyn GuiradoGilla Kaplan
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·F WinauU E Schaible
Nov 7, 2006·Bulletin of Mathematical Biology·Christina WarrenderFrederick Koster
Jul 1, 2011·Immunologic Research·Hannah P Gideon, JoAnne L Flynn
Oct 24, 2003·Current Opinion in Microbiology·Philippe MoingeonMichel de Wilde
Dec 29, 2004·Pathologie-biologie·Jean-Louis Herrmann, Philippe-Henri Lagrange
Jun 5, 2003·International Journal for Parasitology·David N McMurray
May 24, 2003·Vaccine·Donata Medaglini, Arnd Hoeveler
May 27, 2003·Biochimie·Jérôme NigouGermain Puzo
Mar 8, 2003·Microbial Pathogenesis·Jacob MulleradHerve Bercovier
Aug 2, 2003·Research in Microbiology·Ronan O'Toole, Huw D Williams
Jun 26, 2003·Trends in Microbiology·Ludovic TailleuxOlivier Neyrolles
May 22, 2003·Tuberculosis·Stefan H E Kaufmann
Jul 14, 2010·Nature Immunology·Maziar DivangahiSamuel M Behar
Jun 29, 2004·Nature Immunology·Christine L CosmaLalita Ramakrishnan
Apr 7, 2005·Nature Medicine·Stefan H E Kaufmann, Andrew J McMichael
Mar 24, 2004·Nature Reviews. Microbiology·Graham R StewartDouglas B Young
Sep 17, 2004·Nature Reviews. Microbiology·Denise M MonackStanley Falkow
Sep 22, 2009·Médecine sciences : M/S·Brigitte Saint-Joanis, Roland Brosch
Apr 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emanuela GrecoMaurizio Fraziano
Jun 19, 2004·Mediators of Inflammation·Patricia Méndez-SamperioElizabeth García-Martínez
Jan 8, 2003·The Journal of Experimental Medicine·Ludovic TailleuxOlivier Neyrolles
Jan 8, 2003·The Journal of Experimental Medicine·Stefan H E Kaufmann, Ulrich E Schaible
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed AwaisMichael J Keating
Nov 13, 2008·The Journal of Infectious Diseases·Christof GeldmacherMichael Hoelscher
Nov 26, 2009·The Journal of Infectious Diseases·Subash BabuThomas B Nutman
Aug 21, 2013·Genetic Testing and Molecular Biomarkers·Mohammad Y AreeshiShafiul Haque
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Madhan Kumar MurthyAlamelu Raja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved