How can molecular diagnostics contribute to the elimination of human African trypanosomiasis?

Expert Review of Molecular Diagnostics
Philippe Büscher, Stijn Deborggraeve

Abstract

A variety of molecular diagnostic tests for human African trypanosomiasis (HAT) (sleeping sickness) has been developed. Some are effectively used for research and confirmation diagnosis in travel medicine, usually following non-standardized protocols. Others have become commercially available as diagnostic kits. WHO aims to eliminate HAT as a public health problem by the year 2020, and zero transmission by the year 2030. This article gives an overview of the recent progress in molecular diagnostics for sleeping sickness, including the most recent data on test performances. Also discussed is how molecular diagnostics can play an important role in the process toward the elimination of HAT.

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Citations

Apr 21, 2017·PLoS Neglected Tropical Diseases·Serap AksoyJan Van Den Abbeele
Jun 11, 2020·Diagnostics·Emma Michelle Taylor
Sep 4, 2019·Genome Biology·Geoffrey M AttardoSerap Aksoy
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Aug 12, 2021·Clinical Microbiology Reviews·Madeleine J RogersCatherine A Gordon

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African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.