PMID: 9425662Jan 13, 1998Paper

How can we use our growing understanding of gene transcription to discover effective new medicines?

Current Opinion in Biotechnology
D S Latchman

Abstract

Although drugs that target gene transcription are in wide therapeutic use, they were all identified on the basis of their effect on a specific biological process, such as inflammation or hormone responses, and were only subsequently shown to target transcription. The recent progress in understanding the mechanism of action of these drugs, and the mechanisms of transcriptional regulation in general, offers hope for a new generation of drugs isolated on the basis of their ability to modulate either the synthesis of transcription factors, the regulation of their activity by ligands or phosphorylation events, their protein-protein interactions or their binding to DNA.

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Citations

Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·M MinuzzoR Mantovani
Jul 5, 2005·Expert Opinion on Investigational Drugs·D Kletsas, A G Papavassiliou
Jul 13, 2007·Language, Speech, and Hearing Services in Schools·Jennifer A Larsen, Marilyn A Nippold
Apr 12, 2013·Chemistry : a European Journal·Johan R JohanssonJohanna Andersson
Jun 15, 2010·Immunobiology·Denise Richardt-PargmannMarion Jurk

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