How changes in interconnectivity affect the bulk properties of articular cartilage: a fibre network study

Biomechanics and Modeling in Mechanobiology
M A BiltonR J Clarke

Abstract

The remarkable compressive strength of articular cartilage arises from the mechanical interactions between the tension-resisting collagen fibrils and swelling proteoglycan proteins within the tissue. These interactions are facilitated by a significant level of interconnectivity between neighbouring collagen fibrils within the extracellular matrix. A reduction in interconnectivity is suspected to occur during the early stages of osteoarthritic degeneration. However, the relative contribution of these interconnections towards the bulk mechanical properties of articular cartilage has remained an open question. In this study, we present a simple 2D fibre network model which explicitly represents the microstructure of articular cartilage as collection of discrete nodes and linear springs. The transverse stiffness and swelling properties of this fibre network are studied, and a semi-analytic relationship which relates these two macroscopic properties via microscopic interconnectivity is derived. By comparing this derived expression to previously published experimental data, we show that although a reduction in network interconnectivity accounts for some of the observed changes in the mechanical properties of articular cartilage as de...Continue Reading

References

Jan 1, 1985·Connective Tissue Research·N D Broom, D L Marra
Jan 1, 1997·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·D E Shepherd, B B Seedhom
Aug 11, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M A LeRouxL A Setton
Aug 2, 2003·The Journal of Biological Chemistry·Michael A PrattaElizabeth C Arner
Jul 22, 2008·Biophysical Journal·Zhilei L ShenSteven J Eppell
Nov 1, 2009·Sports Health·Alice J Sophia FoxScott A Rodeo
May 20, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Václav KlikaCameron P Brown
Nov 21, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Ying-Chun ChenCameron P Brown
Aug 15, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Mieke NickienNeil D Broom

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Citations

Aug 2, 2021·Journal of Anatomy·Emma Te Tūmanako BrownAshvin Thambyah

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