PMID: 18711432DOI: 10.1038/ni.f.207Aug 20, 2008Paper
How chemokines invite leukocytes to dance
Nature Immunology
Marcus Thelen, Jens V Stein
Abstract
A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.
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