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How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes

Molecular BioSystems

Jul 18, 2008

Adam J Bowen, Anne E Corcoran

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Abstract

Cellular identity is determined by the switching on and off of lineage-specific genes. This dynamic process is regulated by a highly co-ordinated series of chromatin remodelling mechanisms that control DNA accessibility to facilitate transcription, replication and recombination. The ide...read more

Mentioned in this Paper

Immune System
Immunoglobulin Activity
RNA, Untranslated
Transcription, Genetic
Recombination, Genetic
Contraction (Finding)
Cell Nucleus
B-Lymphocyte Mu Chain Gene Rearrangement
Immunoglobulins
Polynucleosomes
Paper Details
References
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How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes

Molecular BioSystems

Jul 18, 2008

Adam J Bowen, Anne E Corcoran

PMID: 18633479

DOI: 10.1039/b719771n

Abstract

Cellular identity is determined by the switching on and off of lineage-specific genes. This dynamic process is regulated by a highly co-ordinated series of chromatin remodelling mechanisms that control DNA accessibility to facilitate transcription, replication and recombination. The ide...read more

Mentioned in this Paper

Immune System
Immunoglobulin Activity
RNA, Untranslated
Transcription, Genetic
Recombination, Genetic
Contraction (Finding)
Cell Nucleus
B-Lymphocyte Mu Chain Gene Rearrangement
Immunoglobulins
Polynucleosomes

Feeds With Similar Papers

Histone Modifications (Keystone)

Histone modifications, including acetylation, phosphorylation, and methylation, play important roles in regulating chromatin structure and nuclear processes. They can also be passed to daughter cells as epigenetic marks. Here is the latest research on histone modification.

Human Immune Variation: Genetics, Gender & Time

Establishing the normal range of phenotypic variation within and between individuals requires consideration of contributions from genetics and the environment. Find the latest research on variations in the human immune system here.

Paper Details
References
  • References79
  • Citations3
12345...
  • References79
  • Citations3
1

Download from

Publisher
PubMed
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