How confident can we be that orthologs are similar, but paralogs differ?

Trends in Genetics : TIG
Romain A Studer, Marc Robinson-Rechavi


Homologous genes are classified into orthologs and paralogs, depending on whether they arose by speciation or duplication. It is widely assumed that orthologs share similar functions, whereas paralogs are expected to diverge more from each other. But does this assumption hold up on further examination? We present evidence that orthologs and paralogs are not so different in either their evolutionary rates or their mechanisms of divergence. We emphasize the importance of appropriately designed studies to test models of gene evolution between orthologs and between paralogs. Thus, functional change between orthologs might be as common as between paralogs, and future studies should be designed to test the impact of duplication against this alternative model.


Mar 13, 2014·Genome Biology and Evolution·Igor B RogozinEugene V Koonin
Jul 30, 2014·Bioinformatics·Erik L L SonnhammerQuest for Orthologs consortium
Sep 10, 2014·Genetics Research International·Igor B Rogozin
Aug 18, 2009·Genome Biology·Alexei V EvsikovCarol J Bult
Feb 25, 2010·BMC Genomics·Sofia BerlinAnn Christin Rönnberg-Wästljung
Jan 1, 2009·Genome Biology and Evolution·Wenfeng Qian, Jianzhi Zhang
May 1, 2010·BMC Evolutionary Biology·Barbara HutterMartina Paulsen
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wenfeng QianJianzhi Zhang
Jun 17, 2011·Briefings in Bioinformatics·Walid H Gharib, Marc Robinson-Rechavi
Jul 9, 2011·Briefings in Bioinformatics·Brigitte BoeckmannChristophe Dessimoz
Aug 9, 2011·BMC Bioinformatics·Kristoffer ForslundErik L L Sonnhammer
Aug 30, 2011·Briefings in Bioinformatics·Pascale GaudetPaul D Thomas
Feb 18, 2012·BMC Bioinformatics·Matti KankainenLiisa Holm
Feb 24, 2012·PLoS Computational Biology·Paul D ThomasGene Ontology Consortium
Jan 12, 2013·PLoS Computational Biology·Nives SkuncaFran Supek
Mar 1, 2013·BMC Bioinformatics·Erik KristianssonOlle Nerman
Oct 22, 2013·BMC Genomics·Ajay PrasadPhilip Zimmermann
Jun 17, 2010·Molecular Biology and Evolution·Romain A Studer, Marc Robinson-Rechavi
Dec 14, 2011·BMC Genomics·Frédéric J J ChainBen J Evans
Apr 5, 2013·Nature Reviews. Genetics·Toni Gabaldón, Eugene V Koonin
Oct 15, 2011·Molecular Plant-microbe Interactions : MPMI·Jeff J Doyle
Nov 8, 2011·Gene·Fredj Tekaia, Edouard Yeramian
Jun 3, 2015·Nucleic Acids Research·Javier IserteCristina Marino-Buslje
Jun 11, 2015·Plant Molecular Biology·Danuta Babula-SkowrońskaJan Sadowski
May 15, 2013·Molecular Phylogenetics and Evolution·Ronald M ClouseWard C Wheeler
Jul 11, 2012·International Journal of Evolutionary Biology·Gabriel V Markov, Ralf J Sommer
Jun 23, 2011·PLoS Computational Biology·Nathan L NehrtMatthew W Hahn
Jul 19, 2012·PLoS Genetics·Kaylin A AdipietroHiroaki Matsunami
Sep 19, 2012·BMC Bioinformatics·Estelle Proux-WéraKenneth H Wolfe


Jan 9, 1997·Nature·W Messier, C B Stewart
Dec 22, 1999·Molecular Biology and Evolution·X Gu
Mar 26, 2003·Molecular Biology and Evolution·Cathal SeoigheDenis C Shields
Jul 2, 2003·Molecular Biology and Evolution·Simonetta GribaldoHervé Philippe
Jul 26, 2003·IUBMB Life·Hervé PhilippeJulien Meunier
Jan 30, 2004·Trends in Genetics : TIG·Dan Graur, William Martin
Mar 17, 2004·PLoS Biology·Jerel C Davis, Dmitri A Petrov
May 4, 2004·Nature Genetics·Zhenglong GuWen-Hsiung Li
Jun 23, 2004·The Plant Cell·Guillaume Blanc, Kenneth H Wolfe
Jul 17, 2004·Genome Research·Cristian I Castillo-DavisGuillaume Achaz
Dec 1, 2004·Annual Review of Genetics·John S Taylor, Jeroen Raes
Aug 16, 2005·Trends in Genetics : TIG·Jerel C Davis, Dmitri A Petrov
Sep 15, 2005·Bioinformatics·Richard J Edwards, Denis C Shields
Nov 16, 2005·Annual Review of Genetics·Eugene V Koonin
Apr 8, 2006·Science·Jamie T BridghamJoseph W Thornton
Jul 1, 2006·Molecular Biology and Evolution·Frédéric G BrunetMarc Robinson-Rechavi
Jul 6, 2006·Trends in Ecology & Evolution·Adam Eyre-Walker
Sep 1, 2006·Molecular Phylogenetics and Evolution·Gavin C ConantPeter F Stadler
Nov 14, 2006·Trends in Genetics : TIG·Evgeny M Zdobnov, Peer Bork
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Benjamin Prud'hommeSean B Carroll
Aug 3, 2007·Molecular Biology and Evolution·Eric W GankoTodd J Vision
Sep 13, 2007·Heredity·M Anisimova, D A Liberles
Nov 17, 2007·Current Opinion in Genetics & Development·Marie Sémon, Kenneth H Wolfe
Jan 15, 2008·BMC Bioinformatics·David M KristensenOlivier Lichtarge
Jan 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aviva PresserRoy Kishony
Mar 19, 2008·Nature Reviews. Genetics·Elliott H Margulies, E Birney
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ben-Yang Liao, Jianzhi Zhang
Jun 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie Sémon, Kenneth H Wolfe
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Shozo Yokoyama
Jun 20, 2008·Genome Research·Romain A StuderMarc Robinson-Rechavi
Jun 20, 2008·Evolution; International Journal of Organic Evolution·Vincent J Lynch, Günter P Wagner
Aug 2, 2008·PLoS Genetics·Carolin KosiolAdam Siepel
Aug 13, 2008·Molecular Biology and Evolution·Pascal-Antoine ChristinGuillaume Besnard
Sep 13, 2008·PLoS Genetics·Jamie T BridghamJoseph W Thornton
Nov 8, 2008·PLoS Computational Biology·Osnat PennTal Pupko
Nov 19, 2008·Nature Reviews. Genetics·Gavin C Conant, Kenneth H Wolfe
Nov 26, 2008·Nature Reviews. Genetics·Henrik KaessmannManyuan Long
Nov 27, 2008·Nucleic Acids Research·T J P HubbardP Flicek
Dec 20, 2008·Current Opinion in Genetics & Development·Vydianathan Ravi, Byrappa Venkatesh
Jan 17, 2009·PLoS Computational Biology·Adrian M Altenhoff, Christophe Dessimoz
Mar 3, 2009·Trends in Biotechnology·Robert Rentzsch, Christine A Orengo

Related Concepts

Teleost fish
Amino Acids, I.V. solution additive
Ncbi Taxonomy
Gene Expression
Receptors, Steroid

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

© 2020 Meta ULC. All rights reserved