How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome.

Lipids in Health and Disease
Alvin BergerBruce Hoff

Abstract

Herein, we expand our previous work on the effects of long chain polyunsaturated fatty acids (LC-PUFA) on the murine hepatic transcriptome using novel statistical and bioinformatic approaches for evaluating microarray data. The analyses focuses on key differences in the transcriptomic response that will influence metabolism following consumption of FUNG (rich in 20:4n6), FISH (rich in 20:5n3, 22:5n3, and 22:6n3) and COMB, the combination of the two. Using a variance-stabilized F-statistic, 371 probe sets (out of 13 K probe sets in the Affymetrix Mu11K chip set) were changed by dietary treatment (P < 0.001). Relative to other groups, COMB had unique affects on murine hepatic transcripts involved in cytoskeletal and carbohydrate metabolism; whereas FUNG affected amino acid metabolism via CTNB1 signaling. All three diets affected transcripts linked to apoptosis and cell proliferation, with evidence FISH may have increased apoptosis and decreased cell proliferation via various transcription factors, kinases, and phosphatases. The three diets affected lipid transport, lipoprotein metabolism, and bile acid metabolism through diverse pathways. Relative to other groups, FISH activated cyps that form hydroxylated fatty acids known to af...Continue Reading

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Citations

Aug 26, 2011·BMC Genomics·Soon-Sen LeowRavigadevi Sambanthamurthi
Aug 29, 2013·BioMed Research International·Elisabetta MurruGianfranca Carta
May 8, 2008·Current Opinion in Lipidology·Donald B Jump
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Feb 3, 2015·Journal of Cellular Physiology·Maria Caterina De RosaMario Felice Tecce
Apr 25, 2007·Cell Biology and Toxicology·F CastanedaJ I Baumbach
Dec 17, 2009·Molecular Nutrition & Food Research·Sebastiano Banni, Vincenzo Di Marzo
Mar 5, 2019·Genome Génome / Conseil National De Recherches Canada·Wassana PrisingkornWei-Min Wang
Dec 7, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley A FelthamMiyoung Suh
Oct 2, 2015·Biochemical Genetics·Yizhe CuiXiuying Zhang
May 5, 2010·Molecular Nutrition & Food Research·Bianca KnochNicole C Roy
Jun 1, 2018·Canadian Journal of Gastroenterology & Hepatology·Anna CieślakOlivier Barbier
Jan 10, 2021·Genes·Tainã Figueiredo CardosoLuciana Correia de Almeida Regitano

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Methods Mentioned

BETA
PCA
nucleotide exchange
dissection
Chip
chips

Software Mentioned

MetaCyc
Ingenuity Systems
Affymetrix
GeneCards
FISH
Ingenuity
Genmapp
Affymetrix Netaffx
COMB
Reactome

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