How distributed processing produces false negatives in voxel-based lesion-deficit analyses

Neuropsychologia
Andrea Gajardo-VidalCathy J Price

Abstract

In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits arising at the word retrieval level. A highly significant lesion-deficit relationship was identified in left temporal and frontal/premotor regions. Post-hoc analyses showed that damage to either of these sites caused the deficit of interest in less than half the affected patients (76/162 = 47%). After excluding all patients with damage to one or both of the identified regions, our second analysis revealed a new region, in the anterior part of the left putamen, which had not been previously detected because many patients had the deficit of interest after temporal or frontal damage that preserved the left putamen. ...Continue Reading

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Citations

Nov 30, 2019·Human Brain Mapping·Christoph SperberHans-Otto Karnath
Nov 13, 2018·Brain : a Journal of Neurology·Andrea Gajardo-VidalCathy J Price
Jan 11, 2020·Frontiers in Human Neuroscience·Gloria PizzamiglioElisabeth Rounis
May 1, 2021·Brain Communications·Sharon GevaCathy J Price
Dec 14, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Christoph Sperber

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Software Mentioned

SPM
SPM12
NiiStat
Matlab

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