How do basophils contribute to Th2 cell differentiation and allergic responses?

International Immunology
Hajime KarasuyamaYoshinori Yamanishi

Abstract

Basophils and mast cells share some features, including basophilic granules in the cytoplasm, cell surface expression of the high-affinity IgE receptor and release of chemical mediators such as histamine. Because of this similarity and their minority status, basophils had often been erroneously considered as minor relatives or blood-circulating precursors of tissue-resident mast cells, and therefore long been neglected or underestimated in immunological studies. Taking advantage of newly developed tools, such as basophil-depleting antibodies and engineered mice deficient for only basophils, recent studies have identified previously unappreciated roles for basophils, distinct from those played by mast cells, in allergic responses, protective immunity against parasitic infections and regulation of other immune cells. In this review, we focus on two topics that we presented and discussed in the 46th Annual Meeting of the Japanese Society for Immunology held in Sendai in December 2017. The first topic is the function of basophils as antigen-presenting cells for driving Th2 cell differentiation. We demonstrated that basophils produce few or no MHC class II (MHC-II) proteins by themselves although they can acquire peptide-MHC-II comp...Continue Reading

Citations

Jun 9, 2020·Journal of Cellular and Molecular Medicine·Huanqin HanQingjun Pan
Apr 23, 2020·Allergy·Cezmi A AkdisOscar Palomares
Mar 27, 2020·Frontiers in Cellular and Infection Microbiology·Marinela ContrerasJosé de la Fuente
Jan 26, 2021·Journal of Immunological Methods·Anne-Emmanuelle BergerClaude Lambert
Jun 3, 2021·Cells·Masafumi NakayamaShin-Ichiro Yamaguchi
May 30, 2021·Annales pharmaceutiques françaises·M Arock
Oct 6, 2021·Pharmacology Research & Perspectives·María de la Paz SarasolaVanina A Medina
Dec 10, 2020·Communications Biology·Chung-Yi WuChi-Huey Wong

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