How do biological systems discriminate among physically similar ions?

The Journal of Experimental Zoology
J M Diamond

Abstract

This paper reviews the history of understanding how biological systems can discriminate so strikingly among physically similar ions, especially alkali cations. Appreciation of qualitative regularities ("permitted sequences") and quantitative regularities ("selectivity isotherms") in ion selectivity grew first from studies of ion exchangers and glass electrodes, then of biological systems such as enzymes and cell membranes, and most recently of lipid bilayers doped with model pores and carriers. Discrimination of ions depends on both electrostatic and steric forces. "Black-box" studies on intact biological membranes have in some cases yielded molecular clues to the structure of the actual biological pores and carriers. Major current problems involve the extraction of these molecules; how to do it, what to do when it is achieved, and how (and if) it is relevant to the central problems of membrane function. Further advances are expected soon from studies of rate barriers within membranes, of voltage-dependent ("excitable") conducting channels, and of increasingly complex model systems and biological membranes.

References

Jan 1, 1975·Journal of Supramolecular Structure·A AbramsD Morris
Jan 1, 1975·The Journal of Membrane Biology·J H Moreno, J M Diamond
Nov 1, 1973·Biochemical and Biophysical Research Communications·E Racker
Feb 18, 1974·Pflügers Archiv : European journal of physiology·E WankeF Conti
Jan 1, 1974·The Journal of Membrane Biology·A E ShamooR W Albers
Jan 5, 1972·Nature: New Biology·E Frömter, J M Diamond
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H M Fishman
Jun 1, 1973·The Journal of General Physiology·B Hille
Jan 1, 1974·The Journal of Membrane Biology·J H Moreno, J M Diamond
May 1, 1972·Quarterly Reviews of Biophysics·D A Haydon, S B Hladky
Dec 31, 1973·The Journal of Membrane Biology·M EisenbergC A Mead
May 30, 1974·Biochimica Et Biophysica Acta·S B Hladky
Jan 1, 1969·Annual Review of Physiology·J M Diamond, E M Wright
Jun 1, 1972·The Journal of General Physiology·B Hille
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Sep 1, 1972·The Journal of General Physiology·R U Muller, A Finkelstein
Jan 1, 1972·The Journal of Membrane Biology·E Frömter
May 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·B C Pressman
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S G McLaughlinS Ciani
Dec 1, 1971·The Journal of General Physiology·B Hille
Dec 1, 1967·The Journal of General Physiology·T E AndreoliD C Tosteson
Feb 24, 1968·Nature·P Mueller, D O RUDIN
Jul 1, 1968·The Journal of General Physiology·A Finkelstein, A Cass
Oct 1, 1965·The Journal of Physiology·W K Chandler, H Meves
Feb 21, 1967·Biochemical and Biophysical Research Communications·P Mueller, D O RUDIN
Jan 1, 1967·The Journal of General Physiology·S Hagiwara, K Takahashi
Feb 27, 1953·The Journal of Physiology·R D KEYNES, H MARTINS-FERREIRA
Oct 25, 1957·Science·G EisenmanJ U CASBY
Mar 1, 1962·Biophysical Journal·G Eisenman
Oct 1, 1959·The Journal of Physiology·A L HODGKIN, P HOROWICZ
Mar 3, 1949·The Journal of Physiology·A L HODGKIN, B KATZ
Dec 1, 1972·The Journal of Membrane Biology·M Montal
Dec 1, 1972·The Journal of Membrane Biology·S HagiwaraN P Rosenthal

Citations

Jan 1, 1980·The Journal of Membrane Biology·B E Ehrlich, J M Diamond
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·L A Roberts

Related Concepts

DNA-dependent ATPase
Calcium
Plasma Membrane
Cell Membrane Permeability
Gallbladder
Hydrogen Bonding
Hydrogen-Ion Concentration
Ion Exchange
Ligands
Membranes, Artificial

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.