Abstract
Bisphosphonates (BPs) have been in use for many years for the treatment of osteoporosis, multiple myeloma, Paget's disease, as well as a variety of other diseases in which there is reduced bone mineral density. Given that bisphosphonates inhibit bone resorption, an important stage of fracture healing; this class of compounds has been widely studied in preclinical models regarding their influence on fracture healing. In animal models, bisphosphonate treatment is associated with a larger fracture callus, coincident with a delay in remodeling from primary woven bone to lamellar bone, but there is no delay in formation of the fracture callus. In humans, de novo use of bisphosphonate therapy after fracture does not appear to have a significant effect on fracture healing. Rarely, patients with long term use of Bisphosphonates may develop an atypical fracture and delay in fracture healing has been observed. In summary, bisphosphonates appear safe for use in the setting of acute fracture management in the upper and lower extremity in humans. While much remains unknown about the effects on healing of long-term bisphosphonates, use prior to "typical" fracture, in the special case of atypical fracture, evidence suggests that bisphosphonat...Continue Reading
References
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C P PeterG A Rodan
Jul 6, 2004·Journal of Pharmacological and Toxicological Methods·Frieder BaussGisbert Sponer
Sep 6, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Negin AmanatDavid G Little
Mar 10, 2007·The New England Journal of Medicine·Socrates E Papapoulos, Serge C L M Cremers
Mar 21, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Negin AmanatDavid Little
Nov 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Louis C GerstenfeldThomas A Einhorn
Feb 20, 2010·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Marcos Almeida MatosRoberto Guarniero
Jun 29, 2010·Bone·Ashley V SloanJiliang Li
Dec 15, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C Colón-EmericUNKNOWN HORIZON Recurrent Fracture Trial
Jan 25, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ufuk TatliSait Polat
Apr 15, 2011·Injury·Richard Marsell, Thomas A Einhorn
Apr 22, 2011·Injury·Susan V Bukata
May 21, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L J KiddM R Forwood
Jul 23, 2011·Bone·Yuji DoiHiroshi Tsumura
Jan 18, 2012·Calcified Tissue International·Takeshi ManabeTetsuji Yamamoto
Jun 12, 2012·Archives of Orthopaedic and Trauma Surgery·Sune Larsson, Nicola L Fazzalari
Sep 21, 2012·The Journal of Bone and Joint Surgery. American Volume·Hyun Sik GongGoo Hyun Baek
Feb 16, 2013·Acta Orthopaedica·Per BosemarkMagnus Tägil
Feb 22, 2013·The Journal of Bone and Joint Surgery. American Volume·Beatrice J EdwardsPaula H Stern
Mar 6, 2013·Acta Pharmacologica Sinica·Ling-jie FuKe-rong Dai
Apr 23, 2013·Clinical Orthopaedics and Related Research·Kenneth A EgolNirmal C Tejwani
Jul 13, 2013·Bone·Neashan MathavanMagnus Tägil
Sep 3, 2013·The Bone & Joint Journal·T SavaridasA H R W Simpson
Oct 24, 2013·The Bone & Joint Journal·S UchiyamaH Kato
Feb 18, 2014·ANZ Journal of Surgery·Andrew Jin-Hean NgMartin Richardson
Jun 7, 2014·Journal of Orthopaedic Surgery and Research·Deting XueZhijun Pan
Sep 18, 2014·Journal of Bone and Mineral Metabolism·Naohisa MiyakoshiYoichi Shimada
Sep 30, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael Hadjiargyrou, Regis J O'Keefe
Oct 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y-T LiZ-L Zhang
Citations
Sep 28, 2016·Expert Opinion on Pharmacotherapy·Letizia Vannucci, Maria Luisa Brandi
Feb 21, 2018·Journal of Orthopaedic Trauma·Stephen L KatesEmil H Schemitsch
Sep 29, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C LavetP Ammann
Jan 24, 2019·Current Osteoporosis Reports·Cheng Cheng, Dolores Shoback
Jan 15, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H P BöglJ Schilcher
Apr 28, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Maximilian LeibleinCaroline Seebach
Dec 14, 2017·Acta Cirúrgica Brasileira·Ana Paula Franttini Garcia Moreno GuimarãesJosé Batista Volpon
Aug 7, 2019·Disease Models & Mechanisms·Monika J TomeckaTom J Carney
Jun 3, 2016·Der Internist·B Harbeck, H Lehnert
Jun 6, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Peeyush N GoelJason W Ashley
May 28, 2019·Der Unfallchirurg·Eric HesseWolfgang Böcker
Mar 20, 2019·Geriatric Orthopaedic Surgery & Rehabilitation·Glenn E LeeGregory J Golladay
Apr 25, 2017·PloS One·Xiaolin LuHuan Wang
Jun 10, 2019·Clinical Hemorheology and Microcirculation·Rebecca RotheJens Pietzsch
Aug 30, 2019·Bone & Joint Research·Julia StarlingerKambiz Sarahrudi
Oct 22, 2020·Current Osteoporosis Reports·Kylie A AlexanderJean-Pierre Levesque
Oct 23, 2020·Tissue Engineering. Part B, Reviews·Zhi ZhengHua Wei
Jan 5, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sidney RobertsJeffrey C Wang
Aug 17, 2020·JBJS Reviews·Justin E HellwinkelZachary M Working
Feb 9, 2021·Frontiers in Endocrinology·Peter KloenNiels Hendrik Bech
Oct 24, 2020·Scientific Reports·Ashwin Ashok NaikVenketesh Sivaramakrishnan
Jan 9, 2021·BioMed Research International·Ourania I KoukouDionysios Alexandros Verettas
Jan 3, 2018·The American Journal of Pathology·Justine TanjayaKang Ting
Apr 16, 2021·The Tohoku Journal of Experimental Medicine·Takashi AkiEiji Itoi
May 18, 2021·PloS One·Cindy J J M van de VenJan A Gossen
May 24, 2021·BMC Musculoskeletal Disorders·Michael R EbyMichael W Hast
Aug 4, 2020·Strategies in Trauma and Limb Reconstruction·Serdar SarginAhmet Aslan
Jun 4, 2021·Archives of Gynecology and Obstetrics·Eda Ureyen OzdemirUmit Inceboz
Jun 26, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yasuaki NakagawaYuki Shinya
Nov 2, 2020·Life Sciences·Ahmad Oryan, Sonia Sahvieh
Jul 24, 2021·Biomaterials·Na-Hyun LeeHae-Won Kim