How do bisphosphonates inhibit bone metastasis in vivo?

Neoplasia : an International Journal for Oncology Research
Pierrick G J FournierPhilippe Clézardin

Abstract

Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated clinical utility in the treatment of patients with osteolytic bone metastases. They also exhibit direct antitumor activity in vitro and can reduce skeletal tumor burden and inhibit the formation of bone metastases in vivo. However, whether such effects are caused by a direct action of bisphosphonates on tumor cells or indirectly through inhibition of bone resorption remains unclear. To address this question, we used here a structural analog of the bisphosphonate risedronate, NE-58051, which has a bone mineral affinity similar to that of risedronate, but a 3000-fold lower bone antiresorptive activity. In vitro, risedronate and NE-58051 inhibited proliferation of breast cancer and melanoma cell lines. In vivo, risedronate and NE-58051 did not inhibit the growth of subcutaneous B02 breast tumor xenografts or the formation of B16F10 melanoma lung metastasis. In contrast to NE-58051, risedronate did inhibit B02 breast cancer bone metastasis formation by reducing both bone destruction and skeletal tumor burden, indicating that the antitumor effect of bisphosphonates is achieved mainly through inhibition of osteoclast-mediated bone resor...Continue Reading

References

Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·A SchmidtG A Rodan
Sep 5, 1997·The Journal of Biological Chemistry·K SkoreyQ Wang
Aug 28, 1997·Biochemical and Biophysical Research Communications·D C CrickC J Waechter
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jeanette WoodJonathan R Green
Jan 28, 2003·Cancer·Sanna-Maria Käkönen, Gregory R Mundy
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toru HiragaToshiyuki Yoneda
Sep 3, 2004·The Journal of Clinical Investigation·Enrico GiraudoDouglas Hanahan
Oct 2, 2004·The Oncologist·Jonathan R Green
Jun 17, 2005·Cancer Research·Philippe ClézardinPierrick G J Fournier
May 3, 2006·Current Opinion in Pharmacology·Fraser P CoxonMichael J Rogers
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anke J RoelofsMichael J Rogers
Aug 19, 2007·Cancer Letters·Verena StresingPhilippe Clézardin

❮ Previous
Next ❯

Citations

Dec 17, 2011·Nuclear Medicine and Biology·Barbara BiesalskiOliver Thews
Jan 13, 2016·International Journal of Cancer. Journal International Du Cancer·Dhivya R SudhanDietmar W Siemann
Feb 13, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lana El OstaNada El Osta
May 17, 2015·Cancer Genetics·Heidrun KarlicFranz Varga
Dec 17, 2014·Cancer Treatment Reviews·Carmen CriscitielloGiuseppe Curigliano
Jun 15, 2014·Bioorganic & Medicinal Chemistry Letters·Waldemar Goldeman, Anna Nasulewicz-Goldeman
Dec 15, 2010·Bone·Philippe ClézardinPeter I Croucher
Aug 30, 2012·Journal of the Egyptian National Cancer Institute·Hamdy A AzimHatem A Azim
Sep 4, 2015·Breast Cancer Research : BCR·Daniele SantiniGiuseppe Tonini
Aug 8, 2014·Frontiers in Chemistry·Jaeok ParkYoula S Tsantrizos
Jun 3, 2016·Journal of Veterinary Internal Medicine·M L ByrumT M Fan
Sep 8, 2016·Biochemistry·Nuno M F S A CerqueiraP A Fernandes
Oct 8, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian SchemSanjay Tiwari
Nov 9, 2016·BMC Cancer·Karina Monroy-CisnerosHumberto Astiazarán-García
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R Gralow
May 24, 2011·Cancers·Megan N ThobeCarrie W Rinker-Schaeffer
Sep 15, 2011·Journal of Cancer Research and Clinical Oncology·Zuo-Lin XiangZhao-You Tang
Apr 26, 2019·Mini Reviews in Medicinal Chemistry·Sonia TeixeiraJoão Costa-Rodrigues
Sep 29, 2017·Frontiers in Pharmacology·Vincenzo MondaAntonietta Messina
Feb 19, 2019·Critical Reviews in Biochemistry and Molecular Biology·Daniel D WallerYoula S Tsantrizos
Mar 8, 2017·Breast Cancer Research : BCR·Jessalyn M UbellackerSandra S McAllister
Oct 13, 2019·Seminars in Cancer Biology·Michela PaselloKatia Scotlandi
Dec 25, 2019·Seminars in Cancer Biology·Ninh M La-BeckAlberto A Gabizon
Aug 28, 2021·Cells·Sandra CasimiroLuis Costa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.