How do children fall asleep? A high-density EEG study of slow waves in the transition from wake to sleep

NeuroImage
Mathilde SpiessFrancesca Siclari

Abstract

Slow waves, the hallmarks of non-rapid eye-movement (NREM) sleep, are thought to reflect maturational changes that occur in the cerebral cortex throughout childhood and adolescence. Recent work in adults has revealed evidence for two distinct synchronization processes involved in the generation of slow waves, which sequentially come into play in the transition to sleep. In order to understand how these two processes are affected by developmental changes, we compared slow waves between children and young adults in the falling asleep period. The sleep onset period (starting 30s before end of alpha activity and ending at the first slow wave sequence) was extracted from 72 sleep onset high-density EEG recordings (128 electrodes) of 49 healthy subjects (age 8-25). Using an automatic slow wave detection algorithm, the number, amplitude and slope of slow waves were analyzed and compared between children (age 8-11) and young adults (age 20-25). Slow wave number and amplitude increased linearly in the falling asleep period in children, while in young adults, isolated high-amplitude slow waves (type I) dominated initially and numerous smaller slow waves (type II) with progressively increasing amplitude occurred later. Compared to young a...Continue Reading

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Citations

Apr 4, 2019·Journal of Neurophysiology·Giulio BernardiFrancesca Siclari
Dec 25, 2019·Sleep·Massimiliano de ZambottiFiona C Baker
Jan 14, 2020·Psychophysiology·Beate E Muehlroth, Markus Werkle-Bergner
Jul 23, 2019·Sleep·Anneke Hertig-GodeschalkDavid R Schreier
Jul 5, 2018·Frontiers in Human Neuroscience·Giulio BernardiGiulio Tononi

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