How do CYP2C19*2 and CYP2C19*17 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?

Drug Metabolism and Personalized Therapy
Valentin Yu SkryabinDmitry A Sychev

Abstract

Background Diazepam is one of the most commonly prescribed tranquilizers for therapy of alcohol withdrawal syndrome (AWS). Despite its popularity, there is currently no precise information on the effect of genetic polymorphisms on its efficacy and safety. The objective of our study was to investigate the effect of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy and safety of diazepam in patients with AWS. Methods The study was conducted on 30 Russian male patients suffering from the AWS who received diazepam in injections at a dosage of 30.0 mg/day for 5 days. The efficacy and safety assessment was performed using psychometric scales and scales for assessing the severity of adverse drug reactions. Results Based on the results of the study, we revealed the differences in the efficacy of therapy in patients with different CYP2C19 681G>A (CYP2C19*2, rs4244285) genotypes: (CYP2C19*1/*1) -8.5 [-15.0; -5.0], (CYP2C19*1/*2 and CYP2C19*2/*2) -12.0 [-13.0; -9.0], p = 0.021. The UKU scale scores, which were used to evaluate the safety of therapy, were also different: (CYP2C19*1/*1) 7.0 [6.0; 12.0], (CYP2C19*1/*2 and CYP2C19*2/*2) 9.5 [8.0; 11.0], p = 0.009. Patients carrying different CYP2C19 -806C>T (CYP2C19*17, rs1224856...Continue Reading

References

Aug 1, 1994·British Journal of Clinical Pharmacology·T AnderssonD J Birkett
Jan 1, 1994·The Annals of Pharmacotherapy·R D Bird, E H Makela
May 20, 1998·Biochemical Pharmacology·T J YangS K Yang
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erin R LepperAlex Sparreboom
Nov 2, 2005·European Journal of Clinical Pharmacology·T FukasawaK Otani
Jul 20, 2007·Journal of Clinical Pharmacy and Therapeutics·T FukasawaK Otani
Aug 28, 2010·Critical Care Medicine·MaryClare Sarff, Jeffrey A Gold
Feb 21, 2014·ACS Chemical Neuroscience·Nicholas E Calcaterra, James C Barrow
May 29, 2015·Journal of Clinical Psychopharmacology·Anna K GarménJonatan D Lindh
Apr 22, 2016·European Journal of Clinical Pharmacology·Manu JoseAdithan Chandrasekaran
Jul 27, 2017·Pharmacogenomics and Personalized Medicine·Mikhail Sergeevich ZastrozhinDmitry Alekseevich Sychev
Oct 12, 2018·Drug and Alcohol Dependence·Neal J BenedictSandra L Kane-Gill
Feb 8, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jin A LeeChristine S Cocanour

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