How Do Gay and Bisexual Men Make Up for Missed PrEP Doses, and What Impact Does Missing a Dose Have on Their Subsequent Sexual Behavior?

AIDS Education and Prevention : Official Publication of the International Society for AIDS Education
Christian GrovJeffrey T Parsons

Abstract

HIV pre-exposure prophylaxis (PrEP) is being adopted by members of key populations, such as gay and bisexual men (GBM). Since adherence to a daily PrEP regimen ensures a maximum protection, it is critical to understand GBM's behavioral responses to having missed PrEP doses. We report on qualitative interviews with GBM taking PrEP. We identified three behavioral responses: (1) 59% continued with their next scheduled dose; (2) 49% described "making up" for a missed dose by taking medication as soon as possible; and (3) 11% reported "doubling" the next PrEP dose. Participants provided potentially contradictory narratives about their sexual behavior after a missed dose: (1) 54% described making no changes; (2) 49% described adjusting their sexual behavior to reduce HIV risk; and (3) 10% said their decision would be contingent upon how many doses were missed. For PrEP prescribers, our data provide a useful lens to understand patients' lived experiences with PrEP.

References

Sep 14, 2012·Science Translational Medicine·Peter L AndersonUNKNOWN iPrEx Study Team
Mar 16, 2013·Current HIV/AIDS Reports·Jared M Baeten, Robert Grant
Nov 20, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sharon M SeifertPeter L Anderson
Jan 21, 2015·Current HIV/AIDS Reports·Douglas S KrakowerKenneth H Mayer
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Jun 14, 2016·Health Communication·Joseph Schwartz, Josh Grimm
Aug 24, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Latesha ElopreMichael J Mugavero
Aug 27, 2016·The Lancet. HIV·David V GliddenRobert M Grant
Feb 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey T ParsonsChristian Grov

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Citations

Jan 1, 2019·International Journal of Sexual Health : Official Journal of the World Association for Sexual Health·Alexa B D'AngeloChristian Grov
Aug 28, 2019·Journal of the American Association of Nurse Practitioners·Minseung ChuCharles Yingling

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