PMID: 9177062Apr 1, 1997Paper

How do genes influence marijuana use? The role of subjective effects

Addiction
M J LyonsM T Tsuang

Abstract

This study investigated determinants of the subjective effects of marijuana and the relationship of subjective effects to marijuana use. Subjects were 8169 twins drawn from the Vietnam Era Twin Registry. Subjects who used marijuana more than five times (n = 2513) reported whether they experienced each of 23 subjective reactions. Factor analysis identified a positive (pleasant) reaction factor and a negative (unpleasant) reaction factor. Both factors were related to duration and frequency of use. Pairs in which both members used marijuana more than five times (MZ = 352 pairs; DZ = 255 pairs) were examined to assess determinants of subjective effects. Approximately one-quarter of the variance in each factor was determined by additive genetic influences; the remaining variance was determined by environmental factors that are not shared by members of a twin pair. The shared or family environment had no detectable influence on either subjective reaction factor.

References

Jan 1, 1979·Drug and Alcohol Dependence·G E McClearn, S M Anderson
Jan 1, 1975·Psychopharmacologia·C Castellano, A Oliverio
Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·E L Gardner, J H Lowinson
Dec 1, 1991·The American Journal of Psychiatry·S L Satel, W S Edell
Jan 1, 1990·Neuropsychobiology·I HindmarchJ S Kerr
Jan 1, 1990·The International Journal of the Addictions·S Zimmerman, A M Zimmerman
Jan 1, 1988·Psychopharmacology·E L GardnerD Morrison
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·H de WitC E Johanson
Aug 1, 1985·Journal of Consulting and Clinical Psychology·S A BrownB A Christiansen
Aug 1, 1974·Journal of Abnormal Psychology·M P Naditch
Dec 13, 1968·Science·A T WeilJ M Nelsen
Jul 1, 1967·The Journal of Nervous and Mental Disease·L Glickman, M Blumenfield
Apr 1, 1994·Archives of General Psychiatry·D H LinszenM E Lenior
Sep 20, 1996·American Journal of Medical Genetics·M T TsuangL Eaves
Jan 1, 1959·Maryland State Medical Journal·I D YALOM
Jan 1, 1991·Drug and Alcohol Review·A Foy

❮ Previous
Next ❯

Citations

Nov 13, 2008·Psychopharmacology·Joseph P SchachtKent E Hutchison
Dec 28, 2000·Addictive Behaviors·K R Merikangas, S Avenevoli
Aug 26, 1998·Schizophrenia Research·J van Os, M Marcelis
May 13, 2010·Psychological Medicine·O J BienvenuK S Kendler
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesca M FilbeyKent E Hutchison
Jan 11, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepak Cyril D'SouzaJohn Krystal
Aug 10, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stéphanie BaggioGerhard Gmel
Sep 27, 2012·Drug and Alcohol Dependence·Arpana AgrawalMichael T Lynskey
Mar 27, 2012·Drug and Alcohol Dependence·Joanna S ZeigerSoo Hyun Rhee
Sep 12, 2009·Psychoneuroendocrinology·Liana FattoreWalter Fratta
Jan 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marissa A EhringerJoanna S Zeiger
Sep 25, 2007·British Journal of Pharmacology·I S McGregor, J C Arnold
Feb 4, 2012·Addiction·Arpana AgrawalMichael T Lynskey
Dec 12, 2013·Addiction·Arpana AgrawalMichael T Lynskey
Aug 27, 2005·Addictive Behaviors·Julia D GrantKathleen K Bucholz
Nov 14, 2014·Journal of Dual Diagnosis·Yilang TangRobert O Cotes
Mar 1, 2017·Depression and Anxiety·Maria M SteenkampWilliam T Anderson
Jun 25, 2015·Substance Abuse : Research and Treatment·L Cinnamon BidwellAdam M Leventhal
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K S KendlerM C Neale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.