How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?

World Journal of Nephrology
Xiaoming Zhou

Abstract

NFAT5 plays a critical role in maintaining the renal functions. Its dis-regulation in the kidney leads to or is associated with certain renal diseases or disorders, most notably the urinary concentration defect. Hypertonicity, which the kidney medulla is normally exposed to, activates NFAT5 through phosphorylation of a signaling molecule or NFAT5 itself. Hypotonicity inhibits NFAT5 through a similar mechanism. More than a dozen of protein and lipid kinases have been identified to contribute to tonicity-dependent regulation of NFAT5. Hypertonicity activates NFAT5 by increasing its nuclear localization and transactivating activity in the early phase and protein abundance in the late phase. The known mechanism for inhibition of NFAT5 by hypotonicity is a decrease of nuclear NFAT5. The present article reviews the effect of each kinase on NFAT5 nuclear localization, transactivation and protein abundance, and the relationship among these kinases, if known. Cyclosporine A and tacrolimus suppress immune reactions by inhibiting the phosphatase calcineurin-dependent activation of NFAT1. It is hoped that this review would stimulate the interest to seek explanations from the NFAT5 regulatory pathways for certain clinical presentations and ...Continue Reading

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Jun 5, 2016·Biochimica Et Biophysica Acta·Xiangyu ZhouKengo Watanabe
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Jun 3, 2021·International Journal of Molecular Sciences·Guangze ZhaoDecheng Yang
Nov 6, 2018·Developmental Neuroscience·Xing-Liang YangBi-Wen Peng

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