DOI: 10.1101/19003871Sep 14, 2019Paper

How do maternal HIV infection and the early nutritional environment influence the development of infants exposed to HIV in utero?

MedRxiv : the Preprint Server for Health Sciences
M. WhiteKristin L Connor


Malnutrition and infectious disease often coexist in socially inequitable contexts. Malnutrition in the perinatal period adversely affects offspring development and lifelong non-communicable disease risk. Less is known about the effects of infectious disease exposure during critical windows of development and health, and links between in utero HIV-exposure in the absence of neonatal infection, perinatal nutritional environments, and infant development are poorly defined. In a pilot study at Kalafong Hospital, Pretoria, South Africa, we aimed to understand how early nutritional environments and in utero HIV-exposure, without infection (HIV exposed uninfected [HEU] infants) may influence infant development. Mother-infant dyads were recruited after delivery and followed until 12 weeks postpartum. Maternal reports of food insecurity were associated with lower maternal nutrient intakes 12 weeks postpartum, and in infants, with lower Apgar scores (five minutes), higher brain-to-body weight ratio at birth and 12 weeks of age, and attainment of fewer large movement and play activities milestones at 12 weeks of age, irrespective of maternal HIV status. Reports of worry about food runout were associated with increased risk of stunting fo...Continue Reading

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