How do outcomes compare between women and men living with HIV in Australia? An observational study

Sexual Health
Michelle L GilesCatherine C O'Connor

Abstract

Background Gender differences vary across geographical settings and are poorly reported in the literature. The aim of this study was to evaluate demographics and clinical characteristics of participants from the Australian HIV Observational Database (AHOD), and to explore any differences between females and males in the rate of new clinical outcomes, as well as initial immunological and virological response to antiretroviral therapy. Time to a new clinical end-point, all-cause mortality and/or AIDS illness was analysed using standard survival methods. Univariate and covariate adjusted Cox proportional hazard models were used to evaluate the time to plasma viral load suppression in all patients that initiated antiretroviral therapy (ART) and time to switching from a first-line ART to a second-line ART regimen. There was no significant difference between females and males for the hazard of all-cause mortality [adjusted hazard ratio: 0.98 (0.51, 1.55), P=0.67], new AIDS illness [adjusted hazard ratio: 0.75 (0.38, 1.48), P=0.41] or a composite end-point [adjusted hazard ratio: 0.74 (0.45, 1.21), P=0.23]. Incident rates of all-cause mortality were similar between females and males; 1.14 (0.61, 1.95) vs 1.28 (1.12, 1.45) per 100 pers...Continue Reading

References

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Jan 8, 2004·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Dawn K SmithUNKNOWN HIV Epidemiology Rsearch Study Group
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Jul 11, 2013·PloS One·Stephen WrightUNKNOWN International Epidemiologic Databases to Evaluate AIDS (IeDEA) Asia-Pacific HIV Observational Database (APHOD)
Mar 7, 2014·Journal of the International AIDS Society·Sasisopin KiertiburanakulUNKNOWN TREAT Asia Studies to Evaluate Resistance (TASER)

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Citations

Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brañas FátimaGuaraldi Giovanni
Jul 15, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meiling ChenFujie Zhang
Feb 8, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fátima BrañasGiovanni Guaraldi

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