PMID: 9008837Dec 1, 1996Paper

How do proteins acquire their three-dimensional structure and stability?

Die Naturwissenschaften
R Jaenicke

Abstract

Proteins are multifunctional in the sense that their specific amino acid sequence simultaneously determines self-organization, function and turnover. Correspondingly, evolution has to compromise between rigidity (stability) and flexibility (function/degradation) to the effect that the free energy of stabilization of proteins is the equivalent of only a few weak interactions (delta Gstab = 45 +/- 15 kJ.mol-1). Molecular adaptation of thermophiles, psychrophiles and other extremophiles is accomplished by extrinsic factors that are not encoded in the amino acid sequence, or by minute local structural changes involving mainly ion pairs and hydrophobic side chains. The acquisition of the native three-dimensional structure may be described by single- or multiple-pathway folding and association, where the fast collapse of the polypeptide chain leads to molten-globule-like states; subsequent shuffling reactions yield structured monomers which, in the case of oligomers, undergo specific association to form the native functional state. The rate-limiting steps (cysteine oxidation, proline isomerization, subunit assembly) are catalyzed or directed by enzymes or chaperones.

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Citations

Sep 19, 2009·Applied Biochemistry and Biotechnology·Om Prakash, Nivedita Jaiswal
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M TeheiG Zaccai
Jun 14, 2005·Biochimica Et Biophysica Acta·Moeava Tehei, Giuseppe Zaccai
Jul 5, 2005·Expert Opinion on Investigational Drugs·C R Middaugh, K L Edwards
Mar 11, 2010·Biochimica Et Biophysica Acta·María Victoria FrassaHoracio Heras
Aug 9, 2007·The FEBS Journal·Moeava Tehei, Giuseppe Zaccai
Jul 5, 2008·Journal of Molecular Biology·Shoeb AhmadN Madhusudhana Rao
Dec 14, 1999·The Journal of Biological Chemistry·C LesieurF G van der Goot
Oct 6, 2005·The Journal of Biological Chemistry·Moeava TeheiGiuseppe Zaccai
Jun 15, 2007·Chemical Reviews·Fred van Rantwijk, Roger A Sheldon

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