How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Post-cholecystectomy Patients and the Background Population?

World Journal of Surgery
Viktor Wanjura, Gabriel Sandblom

Abstract

Previous studies have indicated a correlation between indication for cholecystectomy and long-term gastrointestinal quality-of-life (QoL). The aim of the present study was to compare QoL in a post-cholecystectomy cohort with the background population and with historical controls. A post-cholecystectomy study group (on average 4 years after cholecystectomy) was compared with a control group from the background population using the Gastrointestinal Quality-of-Life Index (GIQLI). EQ-5D scores were compared with expected scores derived from recent historical data. The post-cholecystectomy study group (N = 451) had better QoL measured by the EQ-5D compared with historical controls (p < 0.001), similar total GIQLI scores as the control group (N = 390), but scored worse on the GIQLI gastrointestinal symptoms subscale score (p < 0.001). The results include an item-by-item breakdown of the GIQLI questionnaire where the scores for diarrhea, bowel urgency, bloating, regurgitation, abdominal pain, flatus, fullness, nausea, uncontrolled stools, belching, heartburn, restricted eating, and bowel frequency were found to be significantly lower (i.e. worse) in the post-cholecystectomy cohort than in the control group. The opposite was true for r...Continue Reading

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Citations

Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fan ZhangXinan Wu
Mar 14, 2019·Annals of Hepato-biliary-pancreatic Surgery·Malcolm H W MakVishalkumar G Shelat
Sep 6, 2018·Annals of Surgical Treatment and Research·Hongbeom KimSeung Eun Lee
Feb 27, 2019·Diseases of the Colon and Rectum·Stefan T van DijkUNKNOWN Dutch Diverticular Disease (3D) Collaborative Study Group
May 14, 2021·World Journal of Surgery·Alexia FarrugiaRamesh P Arasaradnam

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