How do so few control so many?

Cell
Kim Nasmyth

Abstract

The separation of sister chromatids at the metaphase-to-anaphase transition is triggered by a protease called separase that is activated by the destruction of an inhibitory chaperone (securin). This process is mediated by a ubiquitin protein ligase called the anaphase-promoting complex or cyclosome (APC/C), along with a protein called Cdc20. It is vital that separase not be activated before every single chromosome has been aligned on the mitotic spindle. Kinetochores that have not yet attached to microtubules catalyze the sequestration of Cdc20 by an inhibitor called Mad2. Recent experiments shed important insight into how Mad2 molecules bound to centromeres through their association with a protein called Mad1 might be transferred to Cdc20 and thereby inhibit securin's destruction.

References

May 4, 2007·Molecular Genetics and Genomics : MGG·Kellie E BarbaraGeorge M Santangelo
Jun 16, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Veit SchubertAndreas Houben
Dec 16, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhonglin HaoJohn Cowell
Mar 21, 2008·Nature·Daniele GuardavaccaroMichele Pagano
Jan 23, 2010·Nature Reviews. Cancer·Juan-Manuel SchvartzmanRobert Benezra
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Edward D Salmon
Aug 24, 2013·Nature Reviews. Molecular Cell Biology·H Christian Reinhardt, Michael B Yaffe
Dec 17, 2008·Molecular BioSystems·Jianhui Yao, Xiangwei He
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Esther EytanAvram Hershko
Jun 10, 2011·Molecular Biology of the Cell·Deike J OmnusPer O Ljungdahl
Jun 10, 2010·Bioinformatics·Ariel JaimovichNir Friedman
Dec 31, 2005·Biology of Reproduction·Marta Sikora-PolaczekMaria A Ciemerych
Nov 18, 2005·Genes & Development·Florence Couteau, Monique Zetka
Jun 17, 2010·Genes & Development·Courtney H CoschiFrederick A Dick
Apr 28, 2010·Molecular and Cellular Biology·Deyu LiJun-Yong Huang
Nov 18, 2009·Molecular and Cellular Biology·Jianjun LuoMin-Hao Kuo
Feb 28, 2007·Molecular and Cellular Biology·Min LiPumin Zhang
Feb 5, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hemmo MeyerGrzegorz Dobrynin
Nov 6, 2009·Annual Review of Genetics·Kim Nasmyth, Christian H Haering
Jun 8, 2006·Annual Review of Biochemistry·Santanu Kumar GhoshMakkuni Jayaram
Mar 17, 2007·Annual Review of Biochemistry·Stefan WestermannGeorjana Barnes
Aug 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mercedes MontielEugenio Jiménez
Jul 26, 2007·Cell Division·Laura A Díaz-Martínez, Hongtao Yu
Feb 7, 2008·PloS One·Bashar IbrahimPeter Dittrich
Oct 13, 2011·Endocrine-related Cancer·Lisa ZhangElectron Kebebew
Mar 26, 2008·The Journal of Chemical Physics·Jason W Locasale
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·E Revenkova, R Jessberger
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ilana BraunsteinAvram Hershko
Oct 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard P Sear, Martin Howard

Citations

Aug 9, 1991·Cell·R Li, A W Murray
Jan 1, 1994·Annual Review of Genetics·W Y Miyazaki, T L Orr-Weaver
Sep 1, 1994·The Journal of Cell Biology·R B Nicklas, S C Ward
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y LiRobert Benezra
Mar 7, 1998·Science·L H HwangA W Murray
Jun 12, 1998·The Journal of Cell Biology·J C WatersEdward D Salmon
Oct 24, 1998·The Journal of Cell Biology·R H ChenA W Murray
Aug 31, 1999·Genes & Development·W Zachariae, Kim Nasmyth
Mar 4, 2000·Nature Structural Biology·Xuelian LuoG Wagner
Sep 22, 2001·Current Biology : CB·B M Stern, A W Murray
Nov 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christian H Haering, Kim Nasmyth
Mar 17, 2004·Nature Structural & Molecular Biology·Xuelian LuoHongtao Yu
Jun 9, 2004·Current Biology : CB·Bonnie J HowellEdward D Salmon
Feb 8, 2005·Current Biology : CB·Anna De AntoniAndrea Musacchio

Related Concepts

Saccharomyces cerevisiae Proteins
ESP1 protein, S cerevisiae
Cell Cycle Proteins
Mitotic Spindle Apparatus
Mitotic Metaphase
MAD1L1 gene
Mitotic Anaphase
Ubiquitin-Protein Ligase Complexes
Centromere
Endopeptidases

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.