How Do Structurally Distinct Compounds Exert Functionally Identical Effects in Combating Obesity?

Frontiers in Pharmacology
Zhi-Jun DengQing-Ping Zeng

Abstract

Although the concept of inflammatory obesity remains to be widely accepted, a plethora of antibiotics, anti-inflammatory agents, mitochondrial uncouplers, and other structurally distinct compounds with unknown mechanisms have been demonstrated to exert functionally identical effects on weight reduction. Here we summarize a universal mechanism in which weight loss is modulated by mitochondrial biogenesis, which is correlated with conversion from the mitochondria-insufficient white adipose tissue to the mitochondria-abundant brown adipose tissue. This mechanistic description of inflammatory obesity may prove useful in the future for guiding pathology-based drug discovery for weight reduction.

References

May 11, 2005·Biochemical and Biophysical Research Communications·Chu-Yue ChenYoung-Joon Surh
Dec 21, 2005·Biochemical and Biophysical Research Communications·Woo Je LeeJoong-Yeol Park
Jul 11, 2006·Journal of Cell Science·Enzo Nisoli, Michele O Carruba
Jul 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·M BoazJ Wainstein
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Feb 5, 2013·Lipids in Health and Disease·Koji NagaoTeruyoshi Yanagita
Aug 1, 2013·Nature Communications·Alejandro Martin-MontalvoRafael de Cabo
Aug 28, 2013·Nutrition & Diabetes·S HawkesworthA M Prentice
Sep 18, 2013·Biochemical and Biophysical Research Communications·Kook Hwan KimMyung-Shik Lee
Feb 18, 2014·ISRN Obesity·Andrea Lynn MurphyJean Hughes
Apr 18, 2014·Nature·D L Katz
Jul 16, 2014·The Biochemical Journal·Hannah R BridgesJudy Hirst
Jan 27, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Philip J ScarpaceNihal Tümer
Jun 6, 2015·Annals of Nutrition & Metabolism·Jacob C Seidell, Jutka Halberstadt
Nov 17, 2015·Nature Medicine·Nicolas Suárez-ZamoranoMirko Trajkovski
Oct 26, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Luke M FunkCorrine I Voils

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

© 2022 Meta ULC. All rights reserved